Results 71 to 80 of about 644,114 (233)

Complicações cardíacas associadas ao coronavírus [PDF]

, 2022
O presente artigo propõe uma revisão bibliográfica de relatos de casos sobre a evolução do novo coronavírus em pacientes que apresentam comorbidade cardiológica, uma vez que, o progresso da doença em pessoas que manifestam distúrbios cardiovasculares ...
Rodrigues, Lucas Polatschek, Miranda, Karla Karoline Moraes, Bretas, Luciana Pinheiro, Siqueira, Marihá Brum, Alves, Marcela Januzzi   +4 more
core   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Coronavírus: Revisão literária

, 2020
Em 2002 e 2003 ocorreu o primeiro surto relevante do coronavírus em Guangdong na China, expressando-se na Síndrome Respiratória Aguda Grave (SARS-CoV).
Navero dos Reis, Alexandre, Paterlini Araújo dos Santos, Aline, Silva Galo, Daniela   +2 more
core   +1 more source

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

ALTERAÇÕES CONTRATUAIS DECORRENTES DA PANDEMIA DO CORONAVÍRUS [PDF]

, 2021
Resumo: Em 06 de fevereiro de 2020 a lei 13.979/2020 foi sancionada uma lei que dispõe sobre as medidas para enfrentamento da emergência de saúde pública de importância internacional decorrente do ...
Silva Oliveira Resende, Akta, Fiorim Bózoli Bonfim, Mariana, Côrrea de Oliveira, Pâmela   +2 more
core  

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

Raman Analysis of RNA Nucleotide Strands From SARS‐CoV‐2 Variants and Subvariants: A Step Forward in the Definition of “Raman Genome”

Advanced Science, EarlyView.
Main Raman signals in RNA, related to helical backbone, ribofuranose ring, and nitrogenous bases, are affected by secondary structures that cause hyperchromic effects and significantly alter the Raman intensity. ABSTRACT Raman spectra of RNA nucleotide strands extracted from 20 SARS‐CoV‐2 strains, including the original Japanese isolate, Alpha, Beta ...
Giuseppe Pezzotti, Yoshiki Yasukochi, Gianluca Angiola, Takaharu Ueno, Saki Ikegami, Rintaro Okawa, Tetsuya Adachi, Wenliang Zhu, Osam Mazda, Alfio Grillo, Koichiro Higasa, Kazu Okuma   +11 more
wiley   +1 more source

Os Impactos da Pandemia da Covid-19 no Lazer de Adultos e Idosos

Licere, 2020
A pandemia da Covid-19 tem sido marcada por um período de isolamento social. Por isso, há uma tendência das atividades de lazer se alterarem ou se adaptarem às opções dentro das residências.
Olívia Cristina Ferreira Ribeiro, Gustavo José de Santana, Ellen Yukari Maruyama Tengan, Lucas William Moreira da Silva, Elias Antônio Nicolas   +4 more
doaj   +1 more source

Acompanhamento das ações de combate à pandemia do Covi-19 : 1º Boletim Quinzenal

, 2020
Inclui notas explicativas, tabelas e anexos.Comissão Mista no âmbito do Congresso Nacional destinada a acompanhar a situação fiscal e a execução orçamentária e financeira das medidas relacionadas à emergência de saúde pública de importância ...
Brasil. Congresso Nacional. Câmara dos Deputados. Comissão Mista de Acompanhamento das Medidas Relacionadas ao Coronavírus
core