Results 141 to 150 of about 3,864,754 (383)
Advanced Science, EarlyView.Hijacking Host Kinase PIM1: A β‐Coronavirus (OC43) strategy to degrade IFNAR1 and evade antiviral immunity. Human β‐coronaviruses (OC43) exploit the proto‐oncoprotein PIM1 kinase to sabotage innate immunity. Viral RNA/proteins upregulate PIM1, which phosphorylates E3 ligase β‐TrCP1.
Qianya Wan +16 more
wiley +1 more source
Acute pancreatitis in SARS-CoV-2 infection: A case report from Tanzania
SAGE Open Medical Case Reports, 2022 The pandemic caused by the severe acute respiratory syndrome coronavirus 2 has mainly affected the respiratory system but has expanded to other systems, including the gastrointestinal system.
Jamil Suleiman +7 more
doaj +1 more source
International Journal of Molecular Sciences, 2020 Recently, the world has been dealing with a devastating global pandemic coronavirus infection, with more than 12 million infected worldwide and over 300,000 deaths as of May 15th 2020, related to a novel coronavirus (2019-nCoV), characterized by a ...
E. Campione +7 more
semanticscholar +1 more source
Coronavirus HKU1 Infection in the United States [PDF]
Emerging Infectious Diseases, 2006 In 2005, a new human coronavirus, HCoV-HKU1, was identified in Hong Kong. We screened respiratory specimens collected from December 16, 2001, to December 15, 2002, from children
David Ferguson +4 more
openaire +4 more sources
A review of coronavirus infection in the central nervous system of cats and mice. [PDF]
, 2001 Feline infectious peritonitis (FIP) is a common cause of death in cats. Management of this disease has been hampered by difficulties identifying the infection and determining the immunological status of affected cats and by high variability in the ...
Foley, JE, Leutenegger, C
core
The V5A13.1 envelope glycoprotein deletion mutant of mouse hepatitis virus type-4 is neuroattenuated by its reduced rate of spread in the central nervous system. [PDF]
, 1992 Following intracerebral inoculation of adult Balb/c Byj mice, the MHV-4 strain of mouse hepatitis virus (MHV) had an LD50 of less than 0.1 PFU, whereas its monoclonal antibody resistant variant V5A13.1 had an LD50 of 10(4.2) PFU.
Bloom, F +3 more
core +1 more source
The Neglected Role of GSDMD C‐Terminal in Counteracting Type I Interferon Signaling
Advanced Science, EarlyView.The C‐terminal domain of Gasdermin D (GSDMD‐CT) shows functions beyond pyroptosis. GSDMD‐CT negatively regulates IFN‐I signaling during viral infection by triggering autophagic degradation of RIG‐I and TBK1. GSDMD‐CT interacts with retinoic acid‐inducible gene‐I (RIG‐I) and tank‐binding kinase 1 (TBK1), leading to TRIM28‐mediated ubiquitination and ...
Weilv Xu +17 more
wiley +1 more source
A Phase Separation‐Assisted Pre‐Enrichment Method for Ultrasensitive Respiratory Virus Detection
Advanced Science, EarlyView.Conventional biomarker enrichment lacks versatility and specificity. Phase separation‐assisted pre‐enrichment (PSAP) is introduced for concurrent antigen (47×) and RNA (44×) enrichment. Tenfold and fivefold lower detection limits for SARS‐CoV‐2 and Influenza, respectively, were achieved.
Yang Cao +8 more
wiley +1 more source
May Polyphenols Have a Role Against Coronavirus Infection? An Overview of in vitro Evidence
Frontiers in Medicine, 2020 The coronavirus infection is constantly diffusing worldwide and the incidence of death is dramatically increasing, representing one of the greatest disasters in human history.
G. Annunziata +7 more
semanticscholar +1 more source
Human Coronavirus Infections [PDF]
, 1995 The first report of a human coronavirus was in 1965 when Tyrrell and Bynoe (1965) isolated a virus from the nasal washings of a male child. The child had typical symptoms and signs of a common cold and the washing was found to be able to induce common colds in volunteers challenged intranasally.
openaire +2 more sources