Results 171 to 180 of about 3,864,754 (383)
Comparison of the pathogenicity of multiple SARS‐CoV‐2 variants in mouse models
Animal Models and Experimental Medicine, EarlyView.We assessed the pathogenicity of various SARS‐CoV‐2 variants using two distinct mouse models. Our findings indicated that earlier variants, including WH‐09, Beta, and Delta, exhibited greater pathogenicity than later variants. Specifically, the Omicron variant demonstrated reduced pathogenicity, characterized by a shorter disease course and diminished ...
Qi Lv +12 more
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.This study explores Fc engineering to extend nanobody half‐lives in vivo. Herein, it is demonstrated that the circulation half‐life of Nanosota‐3A‐Fc, a novel nanobody with potent neutralizing activity against SARS‐CoV‐2 Omicron BA.1 variant, can be greatly prolonged by introducing M252Y/S254T/T256E (YTE) substitutions in the IgG1 Fc domain, which ...
Geetha Jyothi Vaskuri +9 more
wiley +1 more source
Respiratory infection in mice with sialodacryoadenitis virus, a coronavirus of rats [PDF]
, 1977 P. N. Bhatt +2 more
openalex +1 more source
IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes.
Journal of Clinical Investigation, 2019 Type 1 IFNs (IFN-I) generally protect mammalian hosts from virus infections, but in some cases, IFN-I is pathogenic. Because IFN-I is protective, it is commonly used to treat virus infections for which no specific approved drug or vaccine is available ...
Rudragouda Channappanavar +9 more
semanticscholar +1 more source
B cells and systemic sclerosis interstitial lung disease
Arthritis &Rheumatology, Accepted Article.Interstitial lung disease is an important complication of systemic sclerosis (SSc‐ILD) with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to FDA‐approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of interstitial lung diseases of other systemic autoimmune ...
Nina Goldman +2 more
wiley +1 more source
Detection of Coronavirus Infection of Man by Immunofluorescence [PDF]
, 1977 Arnold S. Monto, Lenore M Rhodes
openalex +1 more source
Essential work, invisible workers: The role of digital curation in COVID‐19 Open Science
Journal of the Association for Information Science and Technology, Volume 76, Issue 4, Page 703-717, April 2025.Abstract In this paper, we examine the role digital curation practices and practitioners played in facilitating open science (OS) initiatives amid the COVID‐19 pandemic. In Summer 2023, we conducted a content analysis of available information regarding 50 OS initiatives that emerged—or substantially shifted their focus—between 2020 and 2022 to address ...
Irene V. Pasquetto +2 more
wiley +1 more source
Infection with Middle East respiratory syndrome coronavirus
Canadian Journal of Respiratory Therapy, 2015 The Middle East respiratory syndrome coronavirus (MERS-CoV) was first recognized as a new febrile respiratory illness in Saudi Arabia in June 2012. As of September 21, 2015, the WHO reported 1569 laboratory-confirmed cases, including at least 554 related
Sami Alsolamy, Yaseen M Arabi
doaj
SEROEPIDEMIOLOGIC SURVEY OF CORONAVIRUS (STRAIN 229E) INFECTIONS IN A POPULATION OF CHILDREN [PDF]
, 1975 H. S. Kaye, Walter R. Dowdle
openalex +1 more source
Coronavirus infection of polarized epithelial cells
Trends in Microbiology, 1995 Epithelial cells are the first host cells to be infected by incoming c oronaviruses. Recent observations in vitro show that coronaviruses are released from a specific side of these polarized cells, and this polarized release might be important for the spread of the infection in vivo.
Horzinek, M.C. +2 more
openaire +5 more sources