Results 51 to 60 of about 16,132 (256)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Three essays on corporate finance [PDF]
, 2014 This thesis focuses on empirical corporate finance by studying several entities' decision-making. In the first chapter, we investigate how local governments in China borrow from banks and at the end drive up housing prices. The mechanism is that local government financing vehicles could purchase land parcels at cheaper prices from the local ...
openaire +4 more sources
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
SAGE OpenThe rapid development of digital finance is breaking the service boundaries of traditional finance and alleviating the corporate financing dilemma, thereby affecting the behavioral decisions of micro-enterprises.
Cuicui Chu, Youjin Lv
doaj +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Perspektif: Jurnal Ilmu-ilmu Sosial, 2016 Development, in addition to the positive impact also brought environmental disaster for many because the environment is considered as an object that connotes commodities and continue to be exploited without taking into account the carrying capacity of ...
Barham Siregar
doaj +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
EnergiesAs global sustainability imperatives increase, understanding how green finance policies and technological innovation influence corporate environmental performance has become a relevant issue.
Sonia Chien-i Chen +2 more
doaj +1 more source
Perspektif: Jurnal Ilmu-ilmu Sosial, 2019 Development, in addition to the positive impact also brought environmental disaster for many because the environment is considered as an object that connotes commodities and continue to be exploited without taking into account the carrying capacity of ...
Barham Siregar
doaj +1 more source