Results 71 to 80 of about 1,170,145 (386)

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

How important are CSR companies for nations’ growth?

Journal of Business Economics and Management, 2013
The paper provides new empirical evidence on the positive link between corporate social responsibility and income growth. Using available data for 26 countries over 2000–2008 we investigate cross-country growth differences by adding new variable ...
Marinko Škare, Tea Golja
doaj   +1 more source

Pengaruh Corporate Social Responsibility terhadap Earning Response Coefficient (Studi Empiris pada Perusahaan Manufaktur yang Terdaftar di BEI 2010 - 2012) [PDF]

, 2016
Penelitian ini bertujuan untuk mengetahui pengaruh informasi Corporate Social Responsibility dalam laporan tahunan Perusahaan terhadap Earning Response Coefficient.
Ibrahim, D. (Desriani)
core  

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

The relationship between corporate social responsibility and shareholder value: an empirical test of the risk management hypothesis

, 2009
Do shareholders gain when managers disperse corporate resources through activities classified as corporate social responsibility (CSR)? Strategy scholars have recently developed a theoretical model that links such activities to shareholder value when a ...
Paul C. Godfrey, Craig B. Merrill, J. Hansen   +2 more
semanticscholar   +1 more source

Corporate governance and corporate social responsibility [PDF]

, 2020
Corporate governance and corporate social responsibilityIn recent decades, the field of corporate governance has increasingly recognized corporate social responsibility (CSR)—the responsibility of firms to serve the interests of a broader set of stakeholders beyond their shareholders—as an important part of the corporate goal.
openaire   +2 more sources

Innovative Corporate Social Responsibility in Botswana: The Debswana Mining Company Study Case [PDF]

, 2011
This paper presents a study case on innovative corporate social responsibility as a very important aspect of management planning and, in the process, explores some trends and new ideas pertaining to corporate social responsibility in mining industries ...
José Ramon Torres Solís, Keonethebe Moroka   +1 more
core   +1 more source

Strategies to reduce the cancer burden and improve access to effective and affordable cancer interventions in Europe

Molecular Oncology, EarlyView.
Comprehensive cancer centre (CCCs) and CCCs of Excellence (CCCoE) integration in healthcare. Through outreach to surrounding community hospitals, CCCs enable wider access to top‐clinical cancer treatments and care, thereby facilitating the swift enrolment of patients into data‐rich clinical trials (PI‐initiated trials testing new concepts, drug ...
Anton Berns, Ulrik Ringborg, Julio Celis, Bengt Jönsson, Michael Baumann   +4 more
wiley   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Do Institutional Investors Drive Corporate Social Responsibility? International Evidence

Journal of Financial Economics, 2017
This paper assesses whether shareholders drive the environmental and social (E&S) performance of firms worldwide. Across 41 countries, institutional ownership is positively associated with E&S performance with additional tests suggests this relation is ...
I. Dyck, Karl V. Lins, Lukáš Roth, Hannes F. Wagner   +3 more
semanticscholar   +1 more source