Results 31 to 40 of about 6,044 (253)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Shared value: a bibliometric review of the literature from the approaches of strategy, corporate social responsibility and stakeholder

Cuadernos de Administración, 2020
The recent rise of the Shared Value (SV) concept justifies the debate about its possible conceptual developments. The objective of this article is to analyze the conceptual evolution of the SV showing its approaches from strategy, corporate social ...
Marcela Maestre-Matos, Andrea Paola Paez Cabas, Jahir Enrique Lombana-Coy   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Assessing Data Imbalance in Financial Distress Prediction: A Comparative Approach of Machine Learning and Economic Models

JOIV: International Journal on Informatics Visualization
This study aims to compare the effectiveness of machine learning models and economic models in predicting corporate bankruptcy, with a focus on addressing the issue of data imbalance.
Dyah Sulistyowati Rahayu, Heru Suhartanto, Zaäfri Ananto Husodo   +2 more
doaj   +1 more source

Evaluating the Corporate Tax Performance and Analyzing the Tax Trends through the Utilization of Data Mining Algorithms [PDF]

تحقیقات مالی, 2015
There is always a considerable difference between the corporate performance and the tax levy that is identified by the taxation authorities which has become a common practice.
Babak Sohrabi, Iman Raeesi Vanani, Vahideh Ghanooni Shishone   +2 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

An Explainable Voting Ensemble Framework for Early-Warning Forecasting of Corporate Financial Distress

Forecasting
Accurate early-warning forecasting of corporate financial distress remains a critical challenge due to nonlinear financial relationships, severe data imbalance, and the high operational costs of false alarms in risk-monitoring systems.
Lersak Phothong, Anupong Sukprasert, Sutana Boonlua, Prapaporn Chubsuwan, Nattakron Seetha, Rotcharin Kunsrison   +5 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Textual Data Mining Applications in the Service Chain Knowledge Management of e-Government [PDF]

Journal of Information Technology Management, 2017
Systems related to knowledge management can improve quality and efficiency of knowledge used for decision making process. Approximately 80 percent of corporate information are in textual data formats.
Jalal Rezaeenour, MohammadReza SheikhBahaei   +1 more
doaj   +1 more source