Results 41 to 50 of about 38,700 (269)

Beyond International Law: The Role of Multinational Corporations in Reducing the Number of Stateless Children

open access: yesTilburg Law Review, 2014
Despite the proliferation of international law designed to eradicate statelessness, the United Nations estimates there are approximately 12 million stateless individuals worldwide, many of which are the children of migrant workers employed in industries ...
Mark K. Brewer
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Expediting Manufacturing Launch Using Integrated Data With AI/ML Analytic Solutions

open access: yesIEEE Journal of the Electron Devices Society
Manufacturing yield, test time and quality are important metrics in new product introduction (NPI) to manufacturing safe launch. A powerful yield management system is crucial to achieve the goal metrics. In this paper, recommended yield management system
Helen Haiying Yu   +9 more
doaj   +1 more source

Evolution of corporate social responsibility standards and their implementation in the strategies of the most powerful corporations: Guidelines for the CSR 5.0 concept

open access: yesInternational Entrepreneurship Review, 2022
Objective: The objective of the article is to assess the advancement of social responsibility (CSR) models of the most powerful transnational corporations (Top TNCs) in terms of the implementation of CSR principles in accordance with the idea of ...
Magdalena Rosińska-Bukowska
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Nuclear Energy and Fossil Gas: Fit as a Sustainable Investment? A Review of Case T-625/22 Austria v Commission on Taxonomy Alignment of Certain Nuclear and Fossil Gas Activities

open access: yesEuropean Journal of Risk Regulation
In its judgment Austria v Commission, the General Court dismissed Austria’s action for annulment of the Complementary Climate Delegated Act (CCDA), which classifies certain nuclear energy and fossil gas activities as taxonomy-eligible transitional ...
Liebrich Hiemstra
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

open access: yesFEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park   +8 more
wiley   +1 more source

The role of transnational food and agriculture corporations in creating and responding to food crises

open access: yesCanadian Food Studies, 2015
Transnational corporations (TNCs) have been important players in the globalization of food and agriculture. The preceding papers focused on the ways in which the modern food system is a result of the growing influence and global expansion of agrifood ...
Caitlin Michelle Scott
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

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