Results 161 to 170 of about 38,565 (293)

Disability, sexuality, and 'cure' in Indra Sinha's Animal's people. [PDF]

Philos Ethics Humanit Med
Bhattacherjee R.
europepmc   +1 more source

Palliative care and new technologies. The use of smart sensor technologies and its impact on the Total Care principle. [PDF]

BMC Palliat Care, 2023
Ott T, Heckel M, Öhl N, Steigleder T, Albrecht NC, Ostgathe C, Dabrock P.   +6 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Phenomenological approach to eating disorders: a scoping review. [PDF]

Front Psychol
Silva EBF, Teles MFRP, de Castro NLES, de Souza CP, Bloc LG.   +4 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The poetics of decline in Julian Barnes's The Lemon Table. [PDF]

Gerontologist
Su C.
europepmc   +1 more source

The abject and the vulnerable: the twain shall meet: reflections on disability in the moral economy [PDF]

, 2019
Hughes, Bill
core   +1 more source

El Otro Encuentro: Gigi Oltavaro-Hormillosa’s Neo-Queer Precolonial Imagining

, 2007
This essay examines the performance and video art piece Cosmic Blood, by Gigi Otalvaro-Hormillosa, a queer Colombian and Filipina American artist based in the San Francisco Bay Area.
Velasco, Gina
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Editorial: Influence of social determinants on wellbeing in chronic kidney disease patients. [PDF]

Front Public Health
Fradelos EC, Alikari V.
europepmc   +1 more source