Results 101 to 110 of about 249,622 (267)

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan   +29 more
wiley   +1 more source

Paternal Sperm Gnas‐ICR Epigenetic Programming Contributes to PPP‐Like Phenotypes in Female Offspring

open access: yesAdvanced Science, EarlyView.
A paternal glucocorticoid–sperm Gnas‐ICR axis is linked to ovarian endocrine programming in female offspring. Paternal preconception caffeine exposure elevates corticosterone, promotes sperm Gnas‐ICR hypermethylation, and is associated with ovarian Gnas upregulation, cAMP/PKA/CREB–StAR activation, enhanced estradiol synthesis, and PPP‐like phenotypes ...
Jing Huang   +4 more
wiley   +1 more source

Automating Chemical Reasoning in High‐Throughput Phase Identification With a Probabilistic, LLM‐Guided Framework

open access: yesAdvanced Science, EarlyView.
Autonomous laboratories can now synthesize materials faster than experts can interpret the resulting diffraction data. A probabilistic framework combines refinement‐fit metrics with large language model‐derived chemical reasoning to rank competing phase interpretations and flag those unsuitable for autonomous use.
Olympia Dartsi   +7 more
wiley   +1 more source

Rate of change involving two covarying quantities: Grades 9–12 students' understanding and difficulties

open access: yesAsian Journal for Mathematics Education
This study explored high school students’ understanding of rate of change in physical and functional situations involving two covarying quantities, and the nature of difficulties the students exhibited as they reasoned, represented, and made connections ...
Pragati Bannerjee   +2 more
doaj   +1 more source

Sociodemographic and geographic disparities in COVID-19 booster vaccination in Nueces County, Texas, USA

open access: yesHeliyon
Objective: This paper explores sociodemographic determinants and geographic disparities in COVID-19 booster uptake among fully vaccinated adults in Nueces County, Texas, USA with a population of over 353,000.
Yuxia Huang   +6 more
doaj   +1 more source

Label‐Free Myelin Fingerprinting: An Adult Human Post‐Mortem Brain Slice Platform via Coherent Anti‐Stokes Raman Spectroscopy

open access: yesAdvanced Science, EarlyView.
A serum‐free, air–liquid interface organotypic slice culture model preserves human post‐mortem corpus callosum tissue, successfully recovering from slicing trauma to reflect the donor's underlying disease state. Pairing label‐free Coherent anti‐Stokes Raman scattering (CARS) microscopy with k‐means clustering enables objective, high‐resolution ...
Kasra Roya‐Kouchaki   +5 more
wiley   +1 more source

The Corpus NGT: an Online Corpus for Professionals and Laymen [PDF]

open access: yes, 2008
Contains fulltext : 68356.pdf (Publisher’s version ) (Open Access)
Crasborn, O., Zwitserlood, I.
openaire   +1 more source

StackingNet: Collective Inference Across Independent AI Foundation Models

open access: yesAdvanced Science, EarlyView.
ABSTRACT Artificial intelligence (AI) built on large foundation models has transformed language understanding, computer vision, and reasoning, yet these systems remain isolated and cannot readily share their capabilities. Coordinating the complementary strengths of independently developed, black‐box foundation models is essential for trustworthy ...
Siyang Li   +4 more
wiley   +1 more source

The Knesset Corpus: An Annotated Corpus of Hebrew Parliamentary Proceedings

open access: yesLanguage Resources and Evaluation
Abstract We present the Knesset Corpus, a corpus of Hebrew parliamentary proceedings containing over~30 million sentences (over~384 million tokens) from all the (plenary and committee) protocols held in the Israeli parliament between~1998 and~2022.
Gili Goldin   +4 more
openaire   +2 more sources

CLRe: A Synergistic Dual‐Engine Framework for One‐Step Retrosynthesis Prediction

open access: yesAdvanced Science, EarlyView.
CLRe uses a contrastive difficulty score to order pretrained seq2seq fine‐tuning for retrosynthesis. Reaction embeddings define the ranking score, and a cumulative easy‐to‐hard schedule expands from the easiest subset to the full training set while earlier examples remain active.
Tianhao Su   +5 more
wiley   +1 more source

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