Results 41 to 50 of about 480,630 (163)

The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets

The FEBS Journal, Volume 292, Issue 6, Page 1282-1315, March 2025.
Disturbances of the microbiota–gut–brain axis are evident in people with Huntington's disease (HD) and in HD animal models. Here, we provide an overview of how the trillions of microorganisms residing in the gut, their secretory products, and the microbiota–gut–brain axis may contribute to HD pathogenesis.
Millicent N. Ekwudo, Carolina Gubert, Anthony J. Hannan   +2 more
wiley   +1 more source

Structure, Properties, and Biomedical Activity of Natural Sweeteners Steviosides: An Update

Food Science &Nutrition, Volume 13, Issue 2, February 2025.
Stevioside is a natural sweetener with the characteristics of low calorie and high sweetness. It consists of a wide variety of monomers involved in several biological processes. It has been widely used in the food and pharmaceutical industries. As a substitute for sugar, stevioside also shows good pharmacological activities.
Aoyi Wang, Huiqin Hu, Yadan Yuan, Shiran Mei, Guoxue Zhu, Qiaoyan Yue, Yanliang Zhang, Shujun Jiang   +7 more
wiley   +1 more source

The Effect of Methamphetamine Injection during Post-Lactation on the Ovaries of Adult Rats

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2018
Background and Objectives: Methamphetamine (MAMP) is a central nervous system stimulant, which its consumption has increased among young people. In this study, the effects of methamphetamine were investigated on ovarian tissue structure in immature rats.
Elham Safi, Ali Noori, Ali Asghar Pilehvarian   +2 more
doaj  

The N6‐methyladenosine landscape of ovarian development and aging highlights the regulation by RNA stability and chromatin state

Aging Cell, Volume 24, Issue 2, February 2025.
The combination of FTO knockdown and METTL16 overexpression synergistically increased m6A levels, subsequently downregulating the expression of the H3K9me3 methyltransferase SUV39H1. This resulted in a reduction of H3K9me3 levels and the activation of the ERV1 family, notably LTR7 and LTR12.
Xiujuan Hu, Jiafeng Lu, Chenyue Ding, Jincheng Li, Qinyan Zou, Wenjuan Xia, Chunfeng Qian, Hong Li, Boxian Huang   +8 more
wiley   +1 more source

Epithelial ovarian carcinoma diagnosis by desorption electrospray ionization mass spectrometry imaging [PDF]

, 2016
Ovarian cancer is highly prevalent among European women, and is the leading cause of gynaecological cancer death. Current histopathological diagnoses of tumour severity are based on interpretation of, for example, immunohistochemical staining. Desorption
Brown, R, Doria, ML, Ghaem-Maghami, S, Golf, O, McKenzie, JS, Mroz, A, Phelps, DL, Rosini, F, Speller, A, Strittmatter, N, Takats, Z, Veselkov, K   +11 more
core   +1 more source

Impact of oxidative stress induced by heavy metals on ovarian function

Journal of Applied Toxicology, Volume 45, Issue 1, Page 107-116, January 2025.
Abstract As a crucial organ of the female reproductive system, the ovary has both reproductive and endocrine functions. Oxidative stress refers to an increase in intracellular reactive oxygen species (ROS), which play a role in the normal physiological activity of the ovary. However, excessive ROS can cause damage to the ovary.
Chengqi Xiao, Dongmei Lai
wiley   +1 more source

FUNGAL KERATITIS WITH CORNEAL ULCER IN FARMER

, 2020
Fungal keratitis is important cause of corneal blindness all over the world especially in develoving countries. Fungal Keratitis can diagnosis by slitlamp biomicroscopic examination and culture are essential for early specific diagnosis and must be taken
Nugraha Wahyu Cahyana
semanticscholar   +1 more source

Climate and environment reconstruction during the Medieval Warm Period in Lop Nur of Xinjiang, China [PDF]

, 2008
We made multi-proxy analysis of C-14, grain size, microfossils, plant seeds, and geochemical elements on samples from a profile in the central West Lake of Lop Nur.
Cao QiongYing, Li ShengFeng, Li XuSheng, Ma ChunMei, Ma, CM, Nanjing Univ, Sch Geog & Oceanog Sci, Nanjing 210093, Peoples R China, Wang FuBao, Xia XunCheng   +6 more
core   +1 more source

Histopathological analysis of laparoscopically treated ovarian endometriotic cysts with special reference to loss of follicles.

Human Reproduction, 2002
BACKGROUND The best operative procedure for the laparoscopic treatment of ovarian endometriotic cysts has yet to be defined. The purpose of this study was to evaluate the association between laparoscopic cystectomy and loss of follicles.
T. Hachisuga, T. Kawarabayashi
semanticscholar   +1 more source

Pharmacological Appraisal of Phyllanthus emblica in Letrozole‐Induced Polycystic Ovarian Syndrome Female Rats Model

Journal of Food Biochemistry, Volume 2025, Issue 1, 2025.
Polycystic ovarian syndrome (PCOS) is a complex endocrinological condition affecting women of reproductive age. It may lead to insulin resistance, hyperandrogenism, obesity, cardiovascular issues, and menstrual irregularities. This study aimed to evaluate the ethanolic extract of Phyllanthus emblica (EEPE) against letrozole‐induced PCOS in adult female
Jiangyu Han, Majid Manzoor, Rida Siddique, Hina Manzoor, Subhan Moazzam, Rizwan Rashid Bazmi, Liaqat Hussain, Lin Han   +7 more
wiley   +1 more source