Results 191 to 200 of about 24,257,809 (325)

Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu   +6 more
wiley   +1 more source

Characterization of inflammatory pseudotumors in a large animal model of liver cancer

open access: yesAnimal Models and Experimental Medicine, EarlyView.
CT images in arterial and portal venous phases of liver lesions in Oncopig. Abstract Background The development of relevant and robust large animal models of hepatocellular carcinoma is needed to test new therapeutic strategies for this disease. Transgenic approaches hold promise in addressing this complex problem. One such model, the Oncopig, has been
Erik N. K. Cressman   +4 more
wiley   +1 more source

NG2-Glia Heterogeneity Across Cortical Layers. [PDF]

open access: yesGlia
Barriola S   +5 more
europepmc   +1 more source

Bioinformatics‐based discovery of the involvement of PSAT1 in mediating the anti‐lung adenocarcinoma activity of triptolide

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Transcriptome sequencing was performed on tumor tissues from triptolide‐treated tumor‐bearing mice. The sequencing results were integrated with data from public databases for comprehensive analysis, and potential regulatory targets of triptolide were identified.
Zhiwen Cao   +12 more
wiley   +1 more source

Towards More Robust Nanobioscience: Launching the NanoBubbles Replication Initiative

open access: yesAngewandte Chemie, EarlyView.
The NanoBubbles Reproducibility Initiative investigates the robustness of highly cited articles in nanobioscience. Here, we document the process of setting up the initiative from corpus creation to publishing results. We also present platforms that we adopted and challenges that we faced.
Maha Said   +2 more
wiley   +2 more sources

Persisting Transglutaminase 6 Antibodies in Neurological Gluten‐Related Disorders

open access: yesAnnals of Neurology, EarlyView.
Objective Gluten‐related autoimmunity can cause neurological disease, although the best way to diagnose and monitor such patients is unclear. Serological testing for antibodies against transglutaminase 6 (TG6) has been proposed; however, this is not widely available in clinical practice.
Iain D. Croall   +6 more
wiley   +1 more source

Anatomical Progression of Neuropathology in FTLD‐TDP Type C and Linkage to Annexin A11

open access: yesAnnals of Neurology, EarlyView.
Objective Frontotemporal lobar degenerations (FTLD)‐TDP type C (TDP‐C) is distinguished from other FTLD‐TDP subtypes by 3 unique features: (1) invariable onset in the anterior temporal lobe (ATL), (2) phosphorylated TDP‐43 (pTDP) neurites in cortex, and (3) colocalization of all pTDP deposits with annexin A11 (ANXA11).
Allegra Kawles   +7 more
wiley   +1 more source

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