Results 101 to 110 of about 69,903 (252)

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

Advanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, Xinyu Bao, Renyuan Liu, Meijuan Zhang, Yun Xu   +13 more
wiley   +1 more source

Segmentation of corpus callosum using diffusion tensor imaging: validation in patients with glioblastoma

BMC Medical Imaging, 2012
Background This paper presents a three-dimensional (3D) method for segmenting corpus callosum in normal subjects and brain cancer patients with glioblastoma.
Nazem-Zadeh Mohammad-Reza, Saksena Sona, Babajani-Fermi Abbas, Jiang Quan, Soltanian-Zadeh Hamid, Rosenblum Mark, Mikkelsen Tom, Jain Rajan   +7 more
doaj   +1 more source

Patient‐Mounted Neuro Optical Coherence Tomography for Targeted Minimally Invasive Micro‐Resolution Volumetric Imaging in Brain In Vivo

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Herein, a patient‐mounted neuro optical coherence tomography system that integrates a 5 degrees‐of‐freedom skull‐mounted robot (Skullbot) with a 0.6 mm neuroendoscope for targeted, minimally invasive deep brain imaging, is developed. The system offers high‐resolution imaging with precise deployment, demonstrated through successful tumor imaging in a ...
Chao Xu, Zhiwei Fang, Huxin Gao, Tinghua Zhang, Tao Zhang, Peng Liu, Hongliang Ren, Wu Yuan   +7 more
wiley   +1 more source

Corpus callosum size is highly heritable in humans, and may reflect distinct genetic influences on ventral and rostral regions.

PLoS ONE, 2014
Anatomical differences in the corpus callosum have been found in various psychiatric disorders, but data on the genetic contributions to these differences have been limited.
Girma Woldehawariat, Pedro E Martinez, Peter Hauser, David M Hoover, Wayne W C Drevets, Francis J McMahon   +5 more
doaj   +1 more source

Congenital Zika Virus Infection Impairs Corpus Callosum Development

, 2022
Raíssa R. Christoff, Jefferson H. Quintanilha, Raiane Oliveira Ferreira, Jéssica C. C. G. Ferreira, Daniel Menezes Guimarães, Bruna Valério‐Gomes, Luiza M. Higa, Átila Duque Rossi, Janaina M. Vasconcelos, João Lídio da Silva Gonçalves Vianez Júnior, Maria Bellio, Amílcar Tanuri, Roberto Lent, Patrícia P. Garcez   +13 more
openalex   +1 more source

Early and Innovative Rehabilitation in Warkany Syndrome 2 Associated with Agenesis of the Corpus Callosum: A Case Report [PDF]

, 2022
Carmela Settimo, Lilla Bonanno, Maria Tresoldi, Rosalia Muratore, Francesca Cucinotta, Emanuela Tripodi, Adriana Piccolo, Smeralda Anchesi, Caterina Impallomeni   +8 more
openalex   +1 more source

Infantile‐Onset Ascending Hereditary Spastic Paraplegia due to a Homozygous ALS2 Exons 24–25 Deletion: Expanding the Genotypic Spectrum

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT We describe a novel homozygous intragenic deletion in the ALS2 gene in an 8‐year‐old boy with Infantile‐onset Ascending Hereditary Spastic Paraplegia (IAHSP) and oculomotor apraxia, thereby contributing to the expanding genetic landscape of ALS2‐related disorders.
Vito Luigi Colona, Maria Gnazzo, Silvia Genovese, Gessica Vasco, Lorena Travaglini, Maurizio Sabbadini, Marina Macchiaiolo, Francesco Nicita, Jacopo Sartorelli, Carmelo Piscopo, Enrico Castelli, Enrico Bertini, Andrea Bartuli, Antonio Novelli, Gessica Della Bella, Davide Vecchio   +15 more
wiley   +1 more source

Neuropsychiatric Manifestations of Partial Agenesis of the Corpus Callosum: A Case Report and Literature Review

Case Reports in Psychiatry, 2019
Agenesis of the corpus callosum is a rare congenital defect that has been linked to psychiatric disorders, cognitive deficits, learning disabilities, and developmental delays.
Olusegun Popoola, Olaniyi Olayinka, Heela Azizi, Chiedozie Ojimba, Tasmia Khan, Jisha Kallikkadan, Maleeha Ahmad, Joshua Jay, Cecilia Canale, Sherina Langdon, Alexa Kahn, Deepa Nuthalapati, Sinthuja Jayaraj, Ayesha Mahbub, Olalekan Olaolu, Kodjovi Kodjo, Tolu Olupona, Carolina Nisenoff, Ayodeji Jolayemi   +18 more
doaj   +1 more source

Long‐Read Genome Sequencing Establishes Biallelic Pathogenic Variants in DNM1 With Distinct Functional Effects as the Cause of Early Infantile Developmental and Epileptic Encephalopathy

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous de novo and inherited biallelic pathogenic variants in DNM1 have been reported in association with autosomal dominant (AD) and autosomal recessive (AR) developmental and epileptic encephalopathy, respectively, due to aberrant dynamin function or expression, with each inheritance pattern associated with a different mechanism of ...
Andy Drackley, Merlene Peter, Heba H. Akbari, Jelena Ivanisevic, Alexander Ing, Kelly Regan‐Fendt, Patrick McMullen, Kai Lee Yap   +7 more
wiley   +1 more source

Incidentally discovered colpocephaly and corpus callosum agenesis in asymptomatic adult patient

Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2016
The corpus callosum is the biggest commissural structure located in two brain hemispheres and it ensures the connection between cortical and subcortical neurons.
Huseyin Buyukgol, Muzaffer Gunes, Faik ilik, Fatih Kayhan   +3 more
doaj   +1 more source