Results 191 to 200 of about 976,853 (296)

Multiplexed Tandem Mass Spectrometry Imaging Enables Large‐Scale Isomer Mapping and Annotation in Tissues

Angewandte Chemie, EarlyView.
Parallel mass spectrometry imaging acquires high mass resolution and tandem mass spectrometry images from 108 isolation windows in a single run. Spatial similarity networking clusters product ions by spatial distribution, enabling annotation of isomers and isobars as demonstrated for phospholipids and oxidized cholesterol in mouse and human brain ...
Varun V. Sharma, Gabor Toth, Robert Martinis, Cathrin E. Hansen, Gijs Kooij, Ingela Lanekoff   +5 more
wiley   +2 more sources

B-Mode and Doppler Ultrasonographic Changes in the Corpus Luteum, Uterus, and Uterine Artery During Early Pregnancy in Cows. [PDF]

Life (Basel)
Demir MC, Demir MS, Büyükbaki B, Kuru M, Kaya S, Kaçar C.   +5 more
europepmc   +1 more source

Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu, Zhiyang Zeng, Xinyu Ming, Shuming Yin, Yuting Guan, Liangcai Gao, Dali Li   +6 more
wiley   +1 more source

The postnatal expression of transcripts and proteins in the corpus callosum, as well as its myelinization, is affected by the congenital absence of AQP4. [PDF]

J Physiol Biochem
Mayo F, González-Vinceiro L, Hiraldo-González L, Torres-Rubio I, Calle-Castillejo C, Sobh-Doush E, Ramírez-Lorca R, Echevarría M.   +7 more
europepmc   +1 more source

Optimization and verification of high‐fat diet formulation for establishing a rat model of obesity‐related precocious puberty

Animal Models and Experimental Medicine, EarlyView.
We identified 45% HFD as the optimal formulation to establish a juvenile rat model of obesity‐related precocious puberty. It elicits robust phenotypic (early vaginal opening, obesity), histological (advanced ovarian development), and endocrine (elevated HPG axis hormones) alterations, with leptin‐mediated GnRH secretion as a core mechanistic driver ...
Jiayi Gong, Wei Qian, Deji Song, Kang Li, Li Zhang, Li Shi   +5 more
wiley   +1 more source

Fronto-caudate and callosal microstructural alterations: unveiling multimodal MRI biomarkers in early Parkinson's disease. [PDF]

Br J Radiol
Bernabéu-Sanz Á, Morales S, Naranjo V, Fernández E.   +3 more
europepmc   +1 more source

Transcriptomic validation of a 7,12 Dimethylbenz(a)anthracene (DMBA)‐induced leukemia rat model: Parallels with human leukemogenesis

Animal Models and Experimental Medicine, EarlyView.
7,12‐Dimethylbenz[a]anthracene (DMBA) could induce leukemia and other types of cancers in rat models. Transcriptomics revealed gene expression profile that parallels with human leukemia. DMBA‐induced differential gene expression could validate the developed rat model.
Khaldoon Alsamman, Omar S. El‐Masry
wiley   +1 more source

Constructing and applying a multi-turn psychological support dialogue corpus based on the Helping Skills Chain-of-Thought. [PDF]

Front Psychol
Du L, Li Y, Long Y, Chen S.
europepmc   +1 more source

Brain Morphology and Quantitative Assessment of Sensory Brain Areas in Southern Bluefin Tuna, Thunnus maccoyii (Scombridae, Teleostei). [PDF]

J Comp Neurol
Ha MH, Chapuis L, Glarin R, Moffat B, Wright DK, Dutka TL, Pepperell J, Kerr CC, Yopak KE, Collin SP.   +9 more
europepmc   +1 more source

Basilar Artery Dolichoectasia With Multiple Vessel Compression ("Vessel Sandwich") in Trigeminal Neuralgia: A Case Report and Literature Review. [PDF]

Neurosurg Pract
Corpus-Gutiérrez V, Ocampo-Navia MI, Castro Valle MDP, Ramirez-Caballero C, Barrios-Vidales E, Barajas-Solano P, Chaves-Moreno J, Daza-Ovalle A, Guzman-Ruiz N, Pérez-Pinto F.   +9 more
europepmc   +1 more source