Results 111 to 120 of about 55,874 (301)

A minimal physiologically‐based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti‐LAG‐3 monoclonal antibody

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 460-473, March 2025.
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Robin Michelet, Klas Petersson, Marc C. Huisman, C. Willemien Menke‐van der Houven van Oordt, Iris H. C. Miedema, Andrea Thiele, Ghazal Montaseri, Alejandro Pérez‐Pitarch, David Busse   +8 more
wiley   +1 more source

Corrected QT Interval as a Predictor of Outcomes in Acute Organophosphate Poisoning Cases [PDF]

, 2020
Aliaa Hodeib, Heba Khalifa
openalex   +1 more source

Risperidone and Corrected QT-interval Prolongation in Surface Electrocardiogram

Pakistan Journal of Biological Sciences, 2012
Risperidone is an antipsychotic medication suspected of causing QT prolongation and several cases are reported in this regard. However, available information with respect to its effect on QT interval is limited especially from different settings. The aim of this study was to assess the effect of risperidone in lengthening QT interval among psychotic ...
F, Ranjbar, F, Akbarzadeh, N M, Ahmadi, M, Abbasnejhad   +3 more
openaire   +2 more sources

Functional data analytic approach of modeling ECG T-wave shape to measure cardiovascular behavior

, 2010
The T-wave of an electrocardiogram (ECG) represents the ventricular repolarization that is critical in restoration of the heart muscle to a pre-contractile state prior to the next beat.
Sedransk, Nell, Zhou, Yingchun
core   +1 more source

Efficient, Reversible Lead Adsorption in a Thiol‐Decorated Zirconium‐Metal–Organic Framework

Small, EarlyView.
A thiol‐decorated Zr‐MOF, Zr‐DMSA, efficiently captures Pb(II) from water via mixed S/O chelation enabled by flexible “dangling” ligands, as revealed by solid‐state NMR and pair distribution function analyses. Treatment with 1 M HCl fully reverses Pb binding, regenerating the material for up to 10 consecutive adsorption–desorption cycles.
Timo M. O. Felder, Nazanin Taheri, Till Schertenleib, Anne F. S. Belin, Pattaraphon Rodlamul, Laura Piveteau, Mounir Mensi, Xiao‐Xin Gao, Paul J. Dyson, Mohammad K. Nazeeruddin, Wendy L. Queen   +10 more
wiley   +1 more source

A16-5 Automatic measurement of corrected qt interval in holter ECG as a marker of life-threatening arrhythmias in postmyocardial infarction patients [PDF]

, 2003
Eduard Homs, Vicens Martı́, Pablo Laguna, Josep Guindo, Xavier Viñolas, P. Caminal, Roberto Elosúa, Antoni Bayés‐Genís   +7 more
openalex   +3 more sources

Impact of High Volume Energy Drink Consumption on Electrocardiographic and Blood Pressure Parameters: A Randomized Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Energy drinks have been linked to an increase in emergency room visits and deaths. We aim to determine the impact of energy drinks on electrocardiographic and hemodynamic parameters in young healthy volunteers. Methods and Results A randomized,
Sachin A. Shah, Andy H. Szeto, Raechel Farewell, Allen Shek, Dorothy Fan, Kathy N. Quach, Mouchumi Bhattacharyya, Jasmine Elmiari, Winny Chan, Kate O'Dell, Nancy Nguyen, Tracey J. McGaughey, Javed M. Nasir, Sanjay Kaul   +13 more
doaj   +1 more source

Effect of COVID‐19 medications on corrected QT interval and induction of torsade de pointes: Results of a multicenter national survey

, 2021
Majid Haghjoo, Reza Golipra, Jalal Kheirkhah, Allahyar Golabchi, Javad Shahabi, Saeed Oni‐Heris, Ramin Sami, Marzieh Tajmirriahi, Mehrdad Saravi, Mozhdeh Khatami, Mehran Varnasseri, Mohammadreza Kiarsi, Seyed Fakhreddin Hejazi, Mojtaba Yousefzadeh Rahaghi, Maryam Taherkhani, Haleh Ashraf, Mohammad Sadegh Keshmiri, Mohammad Ali Akbarzadeh, Ali Bozorgi, Fateme Mottaghizadeh, Behnam Hedayat, Mona Heidarali, Azita H. Talasaz   +22 more
openalex   +2 more sources

Rare but relevant: Ibogaine and cardiovascular complications—prolonged QT interval and ventricular arrhythmias

Addiction, EarlyView.
Abstract Revived interest in psychedelic‐assisted therapies has also renewed focus on ibogaine, a psychoactive alkaloid, for its notable anti‐addictive potential. Evidence from observational, open‐label, and limited randomized placebo‐controlled trials indicates that ibogaine and its metabolite noribogaine reduce craving and withdrawal symptoms in ...
Tibor Markus Brunt
wiley   +1 more source

Cardiac Events During Competitive, Recreational, and Daily Activities in Children and Adolescents With Long QT Syndrome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThe 2005 Bethesda Conference Guidelines advise patients with long QT syndrome against competitive sports. We assessed cardiac event rates during competitive and recreational sports, and daily activities among treated long QT syndrome patients ...
Kristina D. Chambers, Virginie Beausejour Ladouceur, Mark E. Alexander, Robyn J. Hylind, Laura Bevilacqua, Douglas Y. Mah, Vassilios Bezzerides, John K. Triedman, Edward P. Walsh, Dominic J. Abrams   +9 more
doaj   +1 more source