Results 111 to 120 of about 52,799 (238)

The isolated working guinea pig heart: A functional and electrophysiological characterisation

Experimental Physiology, EarlyView.
Abstract Small animal isolated perfused hearts have been used for over 150 years for the study of cardiac physiology and pharmacology. The guinea pig heart represents the smallest mammalian heart that replicates key features of the human heart – for example, with respect to cardiac action potential duration, ion channel expression, excitation ...
Grace C. Anderson‐Barker, Michael J Shattock   +1 more
wiley   +1 more source

Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand, Jakub Tomek, Blanca Rodriguez   +2 more
wiley   +1 more source

Heart rate-corrected QT interval: A novel diagnostic biomarker for diabetic peripheral neuropathy. [PDF]

J Diabetes Investig, 2022
Jiang AJ, Gu H, Feng ZR, Ding Y, Xu XH, Yin GP, Zhang WL, Shen ZY, Li Q.   +8 more
europepmc   +1 more source

Corrected QT interval and corrected QT interval dispersion is worthwhile when interpreted with other repolarization measurements

Brazilian Journal of Anesthesiology (English Edition), 2016
Dogan, Mehmet, Yiginer, Omer, Tezcan, Mehmet, Cetindagli, Ibrahim   +3 more
openaire   +5 more sources

In silico modelling of multi‐electrode arrays for enhancing cardiac drug testing on hiPSC‐CM heterogeneous tissues

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the experimental and computational framework for investigating hiPSC‐CM electrophysiology with MEA systems. The MEA‐based model integrates experimental data with phenotype‐specific ionic models and tissue‐level heterogeneity.
Sofia Botti, Rolf Krause, Luca F. Pavarino   +2 more
wiley   +1 more source

Assessing Prolongation of the Corrected QT Interval with Bedaquiline and Delamanid Coadministration to Predict the Cardiac Safety of Simplified Dosing Regimens. [PDF]

Clin Pharmacol Ther, 2022
Tanneau L, Karlsson MO, Rosenkranz SL, Cramer YS, Shenje J, Upton CM, Morganroth J, Diacon AH, Maartens G, Dooley KE, Svensson EM.   +10 more
europepmc   +1 more source

Moxifloxacin Does Increase the Corrected QT Interval [PDF]

Clinical Infectious Diseases, 2001
C M, White, E M, Grant, R, Quintiliani
openaire   +2 more sources

Mathematical model of the zebrafish ventricular cardiomyocyte action potential and calcium transient

The Journal of Physiology, EarlyView.
Abstract figure legend This study presents the development and validation of the first biophysically detailed computational model of the zebrafish ventricular action potential (AP). The model is based on a human cardiomyocyte framework and reparameterized using published and newly generated patch‐clamp recordings of zebrafish ionic currents.
Ludovica Cestariolo, Zachary D. Long, Arie O. Verkerk, Jose M. Ferrero, T. Alexander Quinn, Jose F. Rodriguez Matas   +5 more
wiley   +1 more source

Prognostic Significance of Prolonged Corrected QT Interval in Acute Ischemic Stroke. [PDF]

Front Neurol, 2021
Ahn SH, Lee JS, Kim YH, Yun MS, Han JH, Kim SY, Park MG, Park KP, Kang DW, Kim JS, Kwon SU.   +10 more
europepmc   +1 more source

Electrophysiological characterization of pre‐adolescents born with intrauterine growth restriction: insights from clinical and computational data

The Journal of Physiology, EarlyView.
Abstract figure legend Depolarization and repolarization duration analysis was conducted in preadolescent groups with IUGR and controls using a 12‐lead ECG. Principal component analysis was applied over the 12‐lead ECGs to generate spatially transformed leads better suited for robust ECG fiducial points detection.
Freddy L. Bueno‐Palomeque, Ernesto Zacur, Esther Pueyo, Fàtima Crispi, Pablo Laguna, Ana Mincholé   +5 more
wiley   +1 more source