Results 161 to 170 of about 1,303,482 (284)

hERG1 channels and potential therapeutics for long QT syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend Prolonged QT results from hERG1 channel dysfunction. (A) Physiological anterograde trafficking of hERG1 channels to the plasma membrane, leading to a normal electrocardiogram. (B) Prolonged QT results from the presence of fewer hERG1 channels on the plasma membrane due to decreased anterograde trafficking or reduced function due ...
Elizabeth H. Schneider, Kelly A. Aromolaran, Michael C. Sanguinetti, Ademuyiwa S. Aromolaran   +3 more
wiley   +1 more source

Assessing the risk of drug-induced corrected QT interval prolongation in primary care. [PDF]

Fam Pract
Garg D, Bhella VS, Huyghebaert T.
europepmc   +1 more source

Heart rate-corrected QT interval prolongation is associated with decreased heart rate variability in patients with type 2 diabetes. [PDF]

Medicine (Baltimore), 2022
Cha SA.
europepmc   +1 more source

Experiment‐Anchored Abundance–Coverage Frontiers Define Conditional RHSVV Exposure Requirements in TP53‐Missense Tumors

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Mutant p53 accumulation may complement conformation‐sensitive RHSVV recognition, but the required exposure discrimination depends on tumor coverage and normal‐cell stress. We analyzed 809 tumors and 523 adjacent‐normal specimens from eight CPTAC cohorts.
Takehiro Ishikawa
wiley   +1 more source

Genetic Investigation of Corrected QT Interval Sensitivity to Oral Bepridil Hydrochloride Hydrate in Patients With Atrial Fibrillation. [PDF]

J Am Heart Assoc
Ishibashi N, Furutani M, Nakashima M, Ishida S, Maeda J, Sakai T, Oguri N, Miyamoto S, Miyauchi S, Okamura S, Okubo Y, Tokuyama T, Oda N, Nishiki T, Mitsumori R, Niida S, Ozaki K, Shigemizu D, Itoh H, Nakano Y.   +19 more
europepmc   +1 more source

Effects of trastuzumab and trastuzumab emtansine on corrected QT interval and left ventricular ejection fraction in patients with metastatic (HER2+) breast cancer. [PDF]

Egypt Heart J, 2023
Levicki R, Lovrić Benčić M, Ivanac Vranešić I, Bradić L, Begovac M, Jug J, Dedić Plavetić N.   +6 more
europepmc   +1 more source

Fampridine for Symptomatic Treatment in Chronic Inflammatory Demyelinating Polyneuropathy: A Randomized, Double‐Blinded, Placebo‐Controlled Crossover Study

Journal of the Peripheral Nervous System, Volume 31, Issue 4, December 2026.
ABSTRACT Background and Aims Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is an immune‐mediated neuropathy that may cause persistent disability despite immunoglobulin treatment. Ion channel dysfunction has been demonstrated in CIDP, but no therapies specifically target this mechanism.
Peter Nørregaard Hansen, Lars Markvardsen, Hatice Tankisi, Henning Andersen, Thomas Krøigård, Søren Sindrup   +5 more
wiley   +1 more source

Short-term effect of rosuvastatin versus atorvastatin on the corrected QT interval: a target trial emulation. [PDF]

Eur J Clin Pharmacol
Chen X, Liu Y, Wei W, Xia X, Wu X, Lu X, Hu G, Lu S, Shen Y.   +8 more
europepmc   +1 more source

Corrected QT interval prolongation after ganglionated plexus ablation: myth or reality?-Authors' reply. [PDF]

Europace, 2021
Hermans BJM, Zink MD, Rosmalen FV, Crijns HJGM, Vernooy K, Postema P, Pison L, Schotten U, Delhaas T.   +8 more
europepmc   +1 more source

Collocated Geotechnical and Geophysical Test Dataset at Three Sites in Napier, New Zealand

Earthquake Spectra, Volume 42, Issue 4, November 2026.
Reliable assessment of liquefaction hazard, particularly in the context of groundwater fluctuations associated with hydroclimatic changes and variability between liquefaction assessment methods, necessitates supplementary data and advanced site characterization methods.
Aavash Ghimire, Kaleigh M. Yost, Andrew Stolte, Rolando Orense, Alfonso Mejia   +4 more
wiley   +1 more source