Results 101 to 110 of about 1,549,917 (266)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

QCD Corrections and the Endpoint of the Lepton Spectrum in Semileptonic B Decays

, 1993
Recently, Neubert has suggested that a certain class of nonperturbative corrections dominates the shape of the electron spectrum in the endpoint region of semileptonic $B$ decay. Perturbative QCD corrections are important in the endpoint region. We study
A. Ali, A. Ali, A. Ali, A. Manohar, A.F. Falk, A.F. Falk, Adam F. Falk, Aneesh V. Manohar, B. Grinstein, Elizabeth Jenkins, G. Altarelli, G. Altarelli, G. Corbò, H.D. Politzer, I.I. Bigi, I.I. Bigi, I.I. Bigi, J. Chay, J.C. Collins, J.C. Collins, L. Koyrakh, M. Jeżabek, M. Neubert, M.E. Luke, Mark B. Wise, Mark B. Wise, N. Cabibbo, N. Isgur, N. Isgur, S. Catani, T. Mannel, V. Sudakov   +31 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Correction to “Social justice and the medical librarian” on 107(3) July, page 302. DOI: http://dx.doi.org/10.5195/jmla.2019.712

Journal of the Medical Library Association, 2019
Corrects quote by Martin Luther King Jr. in “Social justice and the medical librarian” on 107(3) July, page 302. DOI: http://dx.doi.org/10.5195/jmla.2019.712.
Katherine G. Akers
doaj   +1 more source

Quantum Corrections for a Bardeen Regular Black Hole

, 2010
In this paper, we study the quantum corrections to the thermodynamical quantities (temperature and entropy) for a Bardeen charged regular black hole by using a quantum tunneling approach over semiclassical approximations.
Javed, Wajiha, Sharif, M.
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Processing Vaccine Misinformation: Recall and Effects of Source Type on Claim Accuracy via Perceived Motivations and Credibility

International Journal of Communication, 2022
This study leverages the persuasion knowledge model (PKM) as a theoretical framework to examine how individuals process attempts at correcting measles, mumps, and rubella vaccine-related misinformation on Facebook. An experiment among U.S.
Michelle A. Amazeen, Arunima Krishna
doaj  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Errata

Journal of Lumbini Medical College, 2017
None
Editor JLMC
doaj  

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source