Results 141 to 150 of about 699,825 (321)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Hubungan Krisis identitas dengan kedisiplinan siswa di SMK Negeri 4 Tanjung Jabung Timur
Teraputik: Jurnal Bimbingan dan KonselingThis research is motivated by student discipline where students commit disciplinary violations at school. This research aims and focuses on revealing the relationship between identity crisis and student discipline at SMK Negeri 4 Tanjung Jabung Timur ...
Dewi Kurnia +2 more
doaj +1 more source
Modeling Comovement among Emerging Stock Markets: The Case of Budapest and Istanbul [PDF]
A double world index model is proposed as an ideal way of characterizing the comovement among emerging stock markets, and applied to Budapest-Istanbul as an interesting case.
Numan Ülkü
core
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Financial Crisis and the Comovements of Housing Sub-markets: Do relationships change after a crisis? [PDF]
This study of the co-movements of the transaction prices and trading volumes reveal that the mean correlation of prices, and trading volumes alike, among different housing sub-markets increases during the market boom.
CHEUNG, W. Y. Patrick +2 more
core +1 more source
Impact of the 2007 financial crisis on the Malaysian banking stocks [PDF]
, 2009 The objective of this study is to examine whether the current global financial crisis has impacted the Malaysian banking stocks. The Dow Jones Industrial Average (DJIA) was used as a proxy for the crisis and it was ascertained that there was a strong ...
Jagdish Mitter Sarna, Kumari Vinod
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Community Structure and Systemic Risk of Bank Correlation Networks Based on the U.S. Financial Crisis in 2008 [PDF]
, 2021 Yajing Huang, Feng Chen
openalex +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Indonesian Stock Market Crisis Observation with Spectral and Composite Index [PDF]
The paper discusses the employment of the index composed from the dynamical tree of correlations among stock prices both with the popularly used standard (conventional) composite one.
Situngkir, Hokky
core +1 more source