Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Correlation of NLR with Oxidative Stress Markers in Sickle Cell Anemia with Vasoocclusive Crisis
, 2019 Atanu Kumar Thakur Satarupa Dash
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The value of optic nerve sheath measurement in patients presenting to the emergency department with hypertensive crisis. [PDF]
Medicine (Baltimore)Danış F +4 more
europepmc +1 more source
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
Did The Global Financial Crisis Alter Cross-market Correlation? A Copula-GARCH Approach
, 2020 Montassar Zayati, Sami Ben Mim
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Social media crisis communication and public engagement during COVID-19 analyzing public health and news media organizations' tweeting strategies. [PDF]
Sci RepSong T, Yu P, Yecies B, Ke J, Yu H.
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TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
The impact of the COVID-19 pandemic on the demand for publicly funded mental health services in Poland (data report 2018-2023). [PDF]
Front Public HealthJuraszek P +4 more
europepmc +1 more source
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Forecasting correlations during the late-2000s financial crisis: The short-run component, the long-run component, and structural breaks [PDF]
, 2014 Francesco Audrino
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