Results 161 to 170 of about 26,060 (217)

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Electron ptychography reveals correlated lattice vibrations at atomic resolution. [PDF]

Nat Commun
Gladyshev A, Haas B, Pekin TC, Boland TM, Schloz M, Rez P, Koch CT.   +6 more
europepmc   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Forest Type Shapes Soil Microbial Carbon Metabolism: A Metagenomic Study of Subtropical Forests on Lushan Mountain. [PDF]

Microorganisms
Xi D, Zhu F, Zhang Z, Zhou S, Zhang J.
europepmc   +1 more source

Mechanistic Analysis of Drug Linker Clearance During Ultrafiltration/Diafiltration of an Antibody–Drug Conjugate

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Ultrafiltration/diafiltration (UF/DF) is a key unit operation in the manufacture of antibody‐drug conjugates (ADCs), commonly utilized for post‐conjugation purification to remove residual Drug Linker (DL) compounds and affect buffer exchange.
Vasudev Tangry, Fara Lyu, Amy Le, Laurie Mlinar, Manish S. Kelkar, Andrew L. Zydney   +5 more
wiley   +1 more source

Integrative taxonomy of <i>Leptotrombidium</i> species collected from murine hosts in Thailand with emphasis on <i>L. deliense</i>. [PDF]

Curr Res Parasitol Vector Borne Dis
Bunmee K, Chaisiri K, Thaenkham U, Sriwichai P, Ruangsittichai J, Samung Y, Dujardin JP, Sumruayphol S.   +7 more
europepmc   +1 more source

Partners or passengers? Revisiting the association between diatoms and aquatic animals

Biological Reviews, EarlyView.
ABSTRACT Numerous studies have revealed the importance of research on the communities capable of colonizing animal surfaces (epibionts) and the animals on which they live (basibionts). Very few studies have considered epizoic diatoms, and there are gaps and biases in our knowledge, including the choice of basibionts, the methods used, and the habitats ...
Gianluca Vacca, Elisa Falasco, Francesca Bona   +2 more
wiley   +1 more source

Timbre Encoding in the Inferior Colliculus. [PDF]

J Neurosci
Fritzinger JB, Carney LH.
europepmc   +1 more source

Can Carbon Strategy Enhance Corporate Productivity? Evidence From Carbon Risk and Opportunity Management

Business Strategy and the Environment, EarlyView.
ABSTRACT Whether corporate carbon management can enhance productive efficiency is central to firms' long‐term competitiveness and determines whether carbon reduction efforts can be sustained beyond regulatory compliance. This study examines how corporate carbon risk and opportunity management affects firm productivity (measured by total factor ...
Nan Huang, Hanlu Fan, Ruoxin Zhu
wiley   +1 more source

Flow molecular dynamics simulations reveal mechano-presentation of von Willebrand factor through glycan-modulated autoinhibitory modules. [PDF]

APL Bioeng
Louis NELR, Zhao YC, Ju LA.
europepmc   +1 more source