Results 41 to 50 of about 610,201 (247)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Entrepreneurship education and entrepreneurship intention among business administration students, Ambrose Alli university, Ekpoma, Edo State, south-south of Nigeria

open access: yesХабаршысы. Экономика сериясы, 2023
This study examined how entrepreneurship education affected students of business administration at Ambrose Alli University, Ekpoma, Nigeria's South-South geopolitical zone to become entrepreneurs. Survey research design was adopted in the study.
Ugbomhe O. Ugbomhe, P. A. Akhator
doaj  

Determinants of Successful Implementation of Early Childhood Development Education by County Governments in Kenya; Implementing Partners Perspective [PDF]

open access: yes, 2019
The purpose of this study was to assess the determinants of successful implementation of Early Childhood Development Education (ECDE) by County Governments in Kenya from the implementing partners‟ perspective.
Ochieng, Otieno John
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Using Linear Regression to Analyze Economics Content Mastery and Learner’s Autonomy Towards English Writing Competence [PDF]

open access: yes, 2019
English is used widely in education area. It is also used in higher education. Many universities put English in the curriculum. In industrial revolution 4.0., English has an important role.
Ratnaningsih, Paskalina Widiastuti
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

THE CONCEPT OF CORRELATION IN THE METHODOLOGY OF TEACHING

open access: yesMetodički Vidici, 2010
The concept of correlation in teaching terminology has several meanings. In addition to the usual understanding of the correlation (interconnection and relationship between the content of subjects taught in school, designated as horizontal and vertical),
Зона В. Мркаљ
doaj  

Relationship between T2* magnetic resonance imaging-derived liver and heart iron content and serum ferritin levels in transfusion-dependent thalassemic children

open access: yesAsian Journal of Transfusion Science, 2018
Context: T2* magnetic resonance imaging (MRI) is being increasingly used for the assessment of organ iron content in thalassemics, but cost is a major prohibitive factor for repeated measurements.
Kiran Suthar   +5 more
doaj   +1 more source

Effectiveness of Technology-based Education on Learning of Dental Students during the Covid-19 Pandemic [PDF]

open access: yesPizhūhish dar Āmūzish-i ̒ulūm-i Pizishkī, 2022
Introduction: Due to the widespread use of technology-based training in the Covid 19 era and  application  of  it  in education,  the present study was conducted to determine the effectiveness of  technology-based education on the learning of dental ...
k pezeshki, S Babaei, E Momeni, M shamsi
doaj  

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