Results 41 to 50 of about 760 (177)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
CHIP-dependent regulation of the actin cytoskeleton is linked to neuronal cell membrane integrity
iScience, 2022 Catarina Dias +9 more
doaj +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
De la frivolidad a la empatía: Nuremberg en el relato de Victoria Ocampo
América, 2016 En 1946, seule invitée sud-américaine, Victoria Ocampo assiste au procès de Nuremberg, à l’invitation du British Council. Sa chronique, « Impresiones de Nuremberg », publiée dans Soledad Sonora quelque quatre années plus tard, frappe par son ton frivole :
Victoria Liendo
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
« La biographie profonde » de Barba Jacob par Fernando Vallejo
América, 2011 Barba Jacob, el mensajero est le récit de vie du poète colombien Porfirio Barba Jacob (1883-1942) sous la plume d’un autre écrivain colombien Fernando Vallejo (1942). Le genre biographique y est décliné en un mélange d’érudition, de créativité littéraire
Carmen Medrano-Ollivier
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Les rapports conflictuels entre la France et les États de Savoie à travers la correspondance de Benoît Cise de Grésy : la prise de Casal (1652) [PDF]
Synergies Italie, 2019 L’objectif de cet article est de présenter les relations conflictuelles entre la France et les États de Savoie, dans les années centrales du XVIIe siècle, à travers la correspondance de Benoît Cise de Grésy, un diplomate savoyard envoyé à Paris.
Cecilia Russo
doaj