Results 161 to 170 of about 556,953 (307)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
From intersubjective correspondence to the counterpart relation-motifs from Carnap's Aufbau in Lewis's counterpart theory and his philosophical methodology. [PDF]
Asian J PhilosMichels R.
europepmc +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Correction: Why do students lose the joy of learning? Evidence from engagement, curiosity, and classroom experience. [PDF]
Front PsycholWang L, Chen X, Sun L, Chen C.
europepmc +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Initiating a Life Skills Module to Prevent Drug Abuse Among Indonesian Adolescents Using Social Cognitive Theory [Letter]. [PDF]
J Multidiscip HealthcBai X.
europepmc +1 more source
FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
A General Structure Theorem for the Nash Equilibrium Correspondence
We consider n--person normal form games where the strategy set of each player is a non--empty compact convex subset of a Euclidean space, and the payoff function of player i is continuous in joint strategies and continuously differentiable and concave in
Predtetchinski, Arkadi
core
How Interviewees Determine What Interviewers Want to Know. [PDF]
Int Rev Soc PsycholNeequaye DA, Lorson A, Barnett HK.
europepmc +1 more source