Results 51 to 60 of about 220,716 (304)

The Dopaminergic Midbrain Encodes the Expected Certainty about Desired Outcomes [PDF]

open access: yes, 2014
Dopamine plays a key role in learning; however, its exact function in decision making and choice remains unclear. Recently, we proposed a generic model based on active (Bayesian) inference wherein dopamine encodes the precision of beliefs about optimal ...
Dolan, Ray   +4 more
core   +2 more sources

The cortical spectrum: A robust structural continuum in primate cerebral cortex revealed by histological staining and magnetic resonance imaging

open access: yesFrontiers in Neuroanatomy, 2022
High-level characterizations of the primate cerebral cortex sit between two extremes: on one end the cortical mantle is seen as a mosaic of structurally and functionally unique areas, and on the other it is seen as a uniform six-layered structure in ...
Yohan J. John   +7 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Stem Anatomy Confirms Tingia unita Is a Progymnosperm

open access: yesBiology, 2023
Tingia Halle, a representative genus of the Cathaysia Flora, has been studied for nearly 100 years, being a small heterosporous tree based on the gross morphology of Tingia unita. However, the systematic affinity of Tingia is uncertain.
Yang Yang, Shi-Jun Wang, Jun Wang
doaj   +1 more source

Dwelling Quietly in the Rich Club: Brain Network Determinants of Slow Cortical Fluctuations

open access: yes, 2015
For more than a century, cerebral cartography has been driven by investigations of structural and morphological properties of the brain across spatial scales and the temporal/functional phenomena that emerge from these underlying features.
Breakspear, Michael   +4 more
core   +1 more source

Editorial: The functional organization of the auditory system [PDF]

open access: yes, 2016
No abstract ...
Kikuchi, Yukiko, Munoz-Lopez, Monica
core   +1 more source

The role of lipid metabolism in neuronal senescence

open access: yesFEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari   +2 more
wiley   +1 more source

What makes a frontal area of primate brain the frontal eye field?

open access: yesFrontiers in Integrative Neuroscience, 2015
The frontal eye field region (FEF) of the oculomotor pathways has been intensely studied. The primary goal of this review is to illustrate the phylogenetic displacement of the FEF locus in primate species. The locus is arrayed along the arcuate sulcus in
Pierre ePouget, Chantal eFrançois
doaj   +1 more source

Autonomous image segmentation and identification of anatomical landmarks from lumbar spine intraoperative computed tomography scans using machine learning: A validation study

open access: yesJournal of Craniovertebral Junction and Spine, 2020
Purpose: Machine-learning algorithms are a subset of artificial intelligence that have proven to enhance analytics in medicine across various platforms. Spine surgery has the potential to benefit from improved hardware placement utilizing algorithms that
Krzyzstof Siemionow   +3 more
doaj   +1 more source

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