Results 51 to 60 of about 222,541 (260)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Cingulum bundle connectivity considering the double-layered cingulate cortex using diffusion-weighted MRI

open access: yesNeuroImage: Reports, 2021
The cingulum bundle (CB) is a fasciculus in the white matter surrounded by the cingulate cortex, which is generally subdivided into the anterior, middle, and posterior parts based on their function and cytology.
Sang-Han Choi   +4 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Study on root architecture of tropical chili peppers (Capsicum frutescens) inoculated with arbuscular mycorrhizal fungi

open access: yesHeliyon
The increasing biotic and abiotic stress on crop growth and development adversely affects crop productivity. Arbuscular Mycorrhizal Fungi (AMF) have garnered significant attention as an eco-friendly management technique, demonstrating multifaceted ...
Erlina Ambarwati   +5 more
doaj   +1 more source

Navigating the complex path between the oxytocin receptor gene (OXTR) and cooperation: an endophenotype approach

open access: yesFrontiers in Human Neuroscience, 2013
Although cooperation represents a core facet of human social behavior there exists considerable variability across people in terms of the tendency to cooperate.
Brian W. Haas   +3 more
doaj   +1 more source

Why musical memory can be preserved in advanced Alzheimer's disease [PDF]

open access: yes, 2015
Musical memory is relatively preserved in Alzheimer's disease and other dementias. In a 7 Tesla functional MRI study employing multi-voxel pattern analysis, Jacobsen et al.
Chételat, Gael   +4 more
core   +2 more sources

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela   +13 more
wiley   +1 more source

Localizing ECoG electrodes on the cortical anatomy without post-implantation imaging

open access: yesNeuroImage: Clinical, 2014
Introduction: Electrocorticographic (ECoG) grids are placed subdurally on the cortex in people undergoing cortical resection to delineate eloquent cortex. ECoG signals have high spatial and temporal resolution and thus can be valuable for neuroscientific
Disha Gupta   +4 more
doaj   +1 more source

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu   +5 more
wiley   +1 more source

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