Results 31 to 40 of about 48,170 (206)

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Functional connectivity underlying postural motor adaptation in people with multiple sclerosis

NeuroImage: Clinical, 2015
A well-characterized neural network is associated with motor learning, involving several brain regions known to have functional and structural deficits in persons with multiple sclerosis (PwMS).
Brett W. Fling, Geetanjali Gera Dutta, Fay B. Horak   +2 more
doaj   +1 more source

(Miscege)nación en O Cortiço

, 2012
Écrit un an après la proclamantion d’indépendance du Brésil, O Cortiço de Aluísio Azevedo dépeint la composition démographique du pays avec un sens du détail naturaliste et examine les dangers potentiels de la miscégénation pour la nouvelle république ...
Price, Brian L.
core   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

Bidirectional Causal Connectivity in the Cortico-Limbic-Cerebellar Circuit Related to Structural Alterations in First-Episode, Drug-Naive Somatization Disorder

Frontiers in Psychiatry, 2018
Background: Anatomical and functional deficits in the cortico-limbic-cerebellar circuit are involved in the neurobiology of somatization disorder (SD).
Ranran Li, Feng Liu, Qinji Su, Zhikun Zhang, Jin Zhao, Ying Wang, Renrong Wu, Jingping Zhao, Wenbin Guo   +8 more
doaj   +1 more source

Do not resonate with actions: sentence polarity modulates cortico-spinal excitability during action-related sentence reading. [PDF]

PLoS ONE, 2011
BACKGROUND: Theories of embodied language suggest that the motor system is differentially called into action when processing motor-related versus abstract content words or sentences.
Marco Tullio Liuzza, Matteo Candidi, Salvatore Maria Aglioti   +2 more
doaj   +1 more source

Reduced Axon Calibre in the Associative Striatum of the Sapap3 Knockout Mouse

Brain Sciences, 2021
Pathological repetitive behaviours are a common feature of various neuropsychiatric disorders, including compulsions in obsessive–compulsive disorder or tics in Gilles de la Tourette syndrome.
Eliana Lousada, Mathieu Boudreau, Julien Cohen-Adad, Brahim Nait Oumesmar, Eric Burguière, Christiane Schreiweis   +5 more
doaj   +1 more source

Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning

Advanced Science, EarlyView.
ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen, Jiahui Xie, Yi Liao, Junyu Li, Longqi Liu, Xin Gao, Hongmin Cai   +6 more
wiley   +1 more source

O cortiço in question

, 2015
Fundação Oswaldo Cruz. Escola Politécnica de Saúde Joaquim Venâncio. Laboratório de Formação Geral na Educação Profissional em Saúde. Rio de Janeiro, RJ, Brasil.Este artigo faz um cotejo de posições críticas acerca do romance O Cortiço de Aluísio Azevedo,
Cruz, João Roberto Maia da
core   +1 more source

Alzheimer pathology disorganizes cortico-cortical circuitry: direct evidence from a transgenic animal model

Neurobiology of Disease, 2004
It has been proposed that Alzheimer disease (AD) is associated with a “disconnection syndrome” due to the gradual loss of morphological and functional integrity of cortico-cortical pathways.
B Delatour, V Blanchard, L Pradier, C Duyckaerts   +3 more
doaj   +1 more source