Results 51 to 60 of about 2,329,584 (350)

Cortical and trabecular bone benefits of mechanical loading are maintained long term in mice independent of ovariectomy. [PDF]

, 2014
Skeletal loading enhances cortical and trabecular bone properties. How long these benefits last after loading cessation remains an unresolved, clinically relevant question.
Barker, Rick G., Fuchs, Robyn K., Galley, Matthew R., George, Lydia A., Guildenbecher, Elizabeth A., Hurd, Andrea L., Richard, Jeffrey S., Warden, Stuart J.   +7 more
core   +1 more source

Post-yield and failure properties of cortical bone.

BoneKEy Reports, 2016
Ageing and associated skeletal diseases pose a significant challenge for health care systems worldwide. Age-related fractures have a serious impact on personal, social and economic wellbeing.
U. Wolfram, J. Schwiedrzik
semanticscholar   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Accumulation of fluorescent advanced glycation end products and carboxymethyl-lysine in human cortical and trabecular bone

Bone Reports, 2022
Chemical crosslinks known as advanced glycation end-products (AGEs) are associated with increased bone fracture risk and deteriorated bone mechanical properties.
Rachana Vaidya, Taraneh Rezaee, Tianna Edwards, Richard Bender, Arune Vickneswaran, Vijaya Chalivendra, Lamya Karim   +6 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

3D Micron-scale Imaging of the Cortical Bone Canal Network in Human Osteogenesis Imperfecta (OI) [PDF]

, 2013
Osteogenesis imperfecta (OI) is a genetic disorder leading to increased bone fragility. Recent work has shown that the hierarchical structure of bone plays an important role in determining its mechanical properties and resistance to fracture. The current
Albert, Carolyne, Busse, Bjoern, Harris, Gerald F., Jameson, John R., Smith, Peter A.   +4 more
core   +1 more source

A comparison of the physical and chemical differences between cancellous and cortical bovine bone mineral at two ages [PDF]

, 2008
To assess possible differences between the mineral phases of cortical and cancellous bone, the structure and composition of isolated bovine mineral crystals from young (1–3 months) and old (4–5 years) postnatal bovine animals were analyzed by a variety ...
A Awonusi, A Bigi, A Kaflak, AH Roufosse, AH Roufosse, AL Boskey, AL Boskey, AL Boskey, AL Boskey, C Rey, C Rey, C Rey, C Rey, C Rey, C Rey, C Rey, C-K Loong, Christian C. Rey, CP Tarnowski, ED Simmons Jr, EE Engleman, EE Wilson, EP Paschalis, EP Paschalis, G Cho, H Ou-Yang, H Ouyang, H-M Kim, HP Klug, Jerome L. Ackerman, K Lundon, LC Bonar, LC Bonar, LC Bonar, Liisa T. Kuhn, LM Miller, LT Kuhn, MA Repo, Marc D. Grynpas, MD Grynpas, Melvin J. Glimcher, MJ Glimcher, N Matsushima, NP Camacho, R Legros, R Legros, RG Handschin, RM Biltz, RZ LeGeros, S Cazalbou, S Mokrzynski, Y Wu, Y Wu, Y Wu, Yaotang Wu   +54 more
core   +1 more source

The effects of bone density and crestal cortical bone thickness on micromotion and peri-implant bone strain distribution in an immediately loaded implant: a nonlinear finite element analysis

Journal of Periodontal & Implant Science, 2016
Purpose This study investigated the effects of bone density and crestal cortical bone thickness at the implant-placement site on micromotion (relative displacement between the implant and bone) and the peri-implant bone strain distribution under ...
T. Sugiura, Kazuhiko Yamamoto, Satoshi Horita, Kazuhiro Murakami, S. Tsutsumi, T. Kirita   +5 more
semanticscholar   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source