Results 251 to 260 of about 28,652 (329)
The N1 peptide specifically targets neurons, enabling cytosolic delivery of fluorescent dyes and proteins for super‐resolution imaging and functional genetic modification. Abstract Efficient delivery of biomolecules into neurons has significant impacts on therapeutic applications in the central nervous system (CNS) and fundamental neuroscience research.
Xiaoqian Ge+16 more
wiley +1 more source
The Locus Coeruleus‐Periaqueductal Gray GABAergic Projection Regulates Comorbid Pain and Depression
LC‐GABA neurons exhibit elevated activity to noxious and aversive stimuli in chronic pain, and their activation alleviates pain‐ and depression‐like behaviors. While LC‐GABA neurons target LC‐NA neurons and GABA and Glu neurons in the vlPAG, they modulate the pain responses of LC‐NA neurons but regulate pain‐ and depression‐like behaviors through their
Yuan Gao+7 more
wiley +1 more source
Recent Advances in Bioresorbable Biomedical Applications: From Materials to Devices
Bioresorbable metal, semiconductor, and polymer materials offer new opportunities for skin‐interfaced platforms and implantable electronic devices by eliminating post‐treatment retrieve surgery and electronic waste through dissolution processes in the natural environment.
Do Yun Park+8 more
wiley +1 more source
Aquaporin-4-independent volume dynamics of astroglial endfeet during cortical spreading depression. [PDF]
Rosic B+7 more
europepmc +1 more source
Abstract INTRODUCTION While RNA editing has been linked to Alzheimer's disease (AD), its specific impact on the transcriptomic landscape in human AD brains remains under explored. METHODS We conducted a comprehensive analysis of RNA editing across nine human brain regions affected by AD, utilizing RNA‐seq data and matched whole‐genome sequencing data ...
Amit Kumar Gupta+5 more
wiley +1 more source
A computational study on the role of glutamate and NMDA receptors on cortical spreading depression using a multidomain electrodiffusion model. [PDF]
Tuttle A, Riera Diaz J, Mori Y.
europepmc +1 more source
Abstract Dementia with Lewy bodies (DLB), a progressive neurodegenerative disease with heterogeneous clinical presentations, greatly impacts patients, caregivers, and society. Despite its frequency, diagnosing and treating DLB remains challenging. Advances in in vivo biomarker assays reflecting underlying pathology are improving disease identification,
Jennifer G. Goldman+19 more
wiley +1 more source
Cortical spreading depression as a site of origin for migraine: Role of CGRP. [PDF]
Close LN+4 more
europepmc +1 more source
Dopamine Transporter Imaging as Objective Monitoring Biomarker in Parkinson's Disease
Objective Although dopamine transporter (DaT) imaging is a valuable diagnostic biomarker, few studies have investigated its utility in objectively monitoring disease progression in patients with Parkinson's disease (PD). To date, no study has established a longitudinal relationship between the DaT signal decline and the motor symptom increase ...
Verena Dzialas+4 more
wiley +1 more source
Increased susceptibility to cortical spreading depression and epileptiform activity in a mouse model for FHM2. [PDF]
Kros L, Lykke-Hartmann K, Khodakhah K.
europepmc +1 more source