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Modeling the Spreading Cortical Depression Wavefront
Annals of the New York Academy of Sciences, 2002Abstract: Spreading cortical depression (SCD) is a wave of depolarization that spreads across the cortex at 2–5 mm/min and is followed by a 5–10 minute reduction in EEG activity. It is assumed that SCD is involved in the pathophysiology of migraine. We present a new model and a visualization technique for the spread of excitation on realistic brain ...
Jens Haueisen, Ugur Baysal
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Epigenetic chromatin modifications in the cortical spreading depression
Brain Research, 2010Preconditioning with Cortical Spreading Depression induces a sort of tolerance to a subsequent episode of ischemia. The mechanism of this tolerance is not clear. We studied if such treatment induces epigenetic chromatin modifications on the hemispheres of rats preconditioned by Cortical Spreading Depression.
Rana G. +5 more
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Chronic daily cortical spreading depressions suppress spreading depression susceptibility
Cephalalgia, 2011Background: Migraine is a disabling chronic episodic disorder. Attack frequency progressively increases in some patients. Incremental cortical excitability has been implicated as a mechanism underlying progression. Cortical spreading depression (CSD) is the electrophysiological event underlying migraine aura, and a headache trigger.
Tao Qin +7 more
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Cortical Spreading Depression and Ischemia in Neurocritical Patients
Neurologic Clinics, 2017Spreading depolarization in cerebral cortex is associated with swelling of neurons, distortion of dendritic spines, massive ion translocation with a large change of the slow electrical potential, and silencing of brain electrical activity. The term spreading depression represents a wave of spontaneous activity of the electrocorticogram that propagates ...
Federico Rodríguez Lucci +1 more
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Excitation and depression of cortical neurones during spreading depression
Experimental Brain Research, 1971Variations in the excitability of individual cortical neurones during the invasion of spreading depression (SD) have been monitored by observing the alterations of spontaneous and L-glutamate-induced firing. Invasion of many neurones during SD is marked by a brief burst of firing which occurs concurrently with the onset of the negative slow ...
S. Ochs, J. W. Phillis
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Oxcarbazepine does not suppress cortical spreading depression
Cephalalgia, 2010Background: Cortical spreading depression is the electrophysiological substrate of migraine aura, and may trigger headache. Recently, chronic treatment with five migraine prophylactic drugs was shown to suppress cortical spreading depression, implicating spreading depression as a common therapeutic target in migraine prophylaxis.Materials and methods ...
Hoffmann, Ulrike +3 more
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Cortical spreading depression induced state dependency
Behavioral Biology, 1974Symmetrical state dependent learning was obtained with bilateral cortical spreading depression using a conditioned heart rate response. Rats, tested under extinction conditions, in a cortical state different from acquisition, showed no retention of the response.
Jay J. Singer, Pamela M. Greenwood
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Suppression of cortical spreading depression in migraine prophylaxis
Annals of Neurology, 2006AbstractObjectiveTopiramate, valproate, propranolol, amitriptyline, and methysergide have been widely prescribed for migraine prophylaxis, but their mechanism or site of action is uncertain. Cortical spreading depression (CSD) has been implicated in migraine and as a headache trigger and can be evoked in experimental animals by electrical or chemical ...
Michael A. Moskowitz +4 more
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The effects of cerebral curvature on cortical spreading depression
Journal of Theoretical Biology, 2019Neuronal activity evokes a localised increase in cerebral blood flow through neurovascular coupling (NVC), a communication system between a group of cells known as a neurovascular unit (NVU). Dysfunctional NVC can lead to pathologies such as cortical spreading depression (CSD), characterised by a slowly propagating wave of neuronal depolarisation and ...
Allanah Kenny +2 more
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SPREADING CORTICAL CONVULSIONS AND DEPRESSIONS
Journal of Neurophysiology, 1953A. Van Harreveld, J. S. Stamm
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