Results 101 to 110 of about 376,320 (257)

Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

Advanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan, Yaqing Wen, Yushan Zhang, Lan Zhang, Jianjian Zhu, Zhen Tang, Ling Jiang, Chuhan Fu, Shu Zhou, Keyi Zhang, Jiangfeng Huang, Li Lei, Jing Chen, Qinghai Zeng   +13 more
wiley   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

Extrafine inhaled corticosteroid therapy in the control of asthma

, 2013
István Ivancsó, Renáta Böcskei, Veronika Müller, Lilla Tamási Department of Pulmonology, Semmelweis University, Budapest, Hungary Abstract: Small airways disease plays an important role in the pathogenesis of asthma,
Ivancsó I, Tamási L, Müller V, Böcskei R   +3 more
core  

Does corticosteroid treatment affect the progression of pediatric IgA nephropathy – a systematic review and meta-analysis

Immunoglobulin A nephropathy (IgAN) is an autoimmune disease in pediatric patients, with corticosteroid (CS) treatment remaining controversial. This meta-analysis evaluates the efficacy and safety of CS in pediatric IgAN patients.
Cynthia Cynthia, Erika Aini Putri, Andro Pramana Witarto, Yoga Eka Prayuda, Wida Ratna Sari, Bebby Shelby, Aditya Primadana   +6 more
core   +1 more source

Clinical pattern of corticosteroid dependent Crohn's disease.

, 1998
OBJECTIVES: Corticosteroid dependency in Crohn's disease (CD) is characterized by the need for chronic use of corticosteroids to maintain clinical remission. Several definitions have been used.
Belaiche, Jacques, Franchimont, Denis, Croes, F, Franchimont, D. P., Louis, Edouard, Croes, F.   +5 more
core   +1 more source

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source

Concomitant Case of Primary Biliary Cirrhosis and Autoimmune Hemolityc Anemia Responding to Corticosteroid and Ursodeoxycholic Acid in Young Woman

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2016
Primary biliary cirrhosis (PBC) is an autoimmune liver disease of unknown etiology and is characterized by chronic progressive cholestasis with destruction of the small intrahepatic bile ducts and associated most commonly with antimitochondrial ...
Susanto H Kusuma, Fardah Akil, Amelia Rifai, Rini R Bachtiar, Numan AS Daud, AM Luthfi Parewangi   +5 more
doaj  

The use of steroids in adult epilepsy: A systematic review

Epilepsia Open
Objective The objective of this study is to systematically review the clinical studies investigating the use of steroids in adult epilepsy. Methods This systematic review utilized Preferred Reporting Items for Systematic Review and Meta‐analysis ...
Ruth Walsh, Colin P. Doherty, Elisabeth Doran   +2 more
doaj   +1 more source

Inadequate quality of administration of intranasal corticosteroid sprays

, 2019
Corine Rollema,1,2 Eric N van Roon,1,2 Tjalling W de Vries3 1Department of Clinical Pharmacy and Pharmacology, Medical Centre Leeuwarden, Leeuwarden, The Netherlands; 2Groningen Research Institute of Pharmacy, Department Pharmaco therapy, Epidemiology ...
Rollema C, van Roon EN, de Vries TW
core