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Radioimmunoassay of Corticotropin - Releasing Hormone
Experimental and Clinical Endocrinology & Diabetes, 2009A specific double antibody radioimmunoassay (RIA) for human-Corticotropin-Releasing Hormone (hCRF) using an antibody to synthetic hCRF was established. This antibody allowed a usable range of 10 pg to 5 ng of CRF per ml in the assay. Comparing the efficiency of various plasma extraction procedures, the extraction with ice-cold methanol was found to be ...
Y, Rückert, W, Rohde, J, Furkert
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Corticotropin-releasing hormone receptors
Biochemical Society Transactions, 2002Corticotropin-releasing hormone (CRH) and related peptides (urocortins, sauvagine, urotensin) play a central role in the co-ordination of autonomic, behavioural, cardiovascular, immune and endocrine responses to stressful stimuli. Their actions are mediated through activation of two types of G-protein-coupled receptors encoded by separate genes.
E W, Hillhouse +3 more
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Corticotropin‐Releasing Hormone and Inflammation
Annals of the New York Academy of Sciences, 1998Abstract: Cortic otropin‐releasing hormone (CRH) is a major regulator of the hypothalamic‐pituitary‐adrenal axis (HPA) and principal coordinator of the stress response. As in stress, intracerebroventricular administration of CRH suppresses the immune system indirectly, via glucocorticoid and/or sympathetic system‐mediated mechanisms.
E L, Webster +3 more
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Proopiomelanocortin, corticotropin releasing hormone and corticotropin releasing hormone receptor genes are expressed in human skin [PDF]
FEBS Letters, 1995 Evidence is provided that human skin, the largest body organ exposed to multiple stressors, expresses proopiomelanocortin (POMC), corticotropin releasing hormone (CRH) and CRH‐receptor (CRHR) genes in vivo. In vitro studies show that POMC and CRHR mRNAs are transcribed in melanocytes, cells derived from the neural crest, and in keratinocytes, cells ...
Ashok Chakraborty, Joseph E Mazurkiewicz
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Corticotropin-Releasing Hormone in Humans*
Endocrine Reviews, 1992I. A Brief History of Corticotropin-Releasing Hormone (CRH) and Vasopressin as Mediators of Pituitary-Adrenal Activation in Humans HARRIS' 1948 hypothesis (1) that anterior pituitary function is regulated by hypothalamic factors released into and carried by the hypothalamic-hypophysial portal blood to the adenohypophysis was not lost upon clinical ...
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Corticotropin-Releasing Hormone: Clinical Applications
Annual Review of Medicine, 1989Corticotropin-releasing hormone, a 41-amino-acid peptide, is an important hypothalamic factor regulating the pituitary secretion of adrenocorticotropic hormone (ACTH). This hormone, while rarely involved in the etiology of Cushing's syndrome, seems to play a major role in the pathogenesis of non-Cushing hypercortisolemic states.
L K, Nieman, D L, Loriaux
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The neuroprotective actions of corticotropin releasing hormone
Ageing Research Reviews, 2005Corticotropin-releasing hormone (CRH) modulates the activity of the hypothalamic-pituitary-adrenal (HPA) axis, and has a key role in mediating neuroendocrine effects that occur in response to stressful stimuli. Disruption of the CRH system however has been shown to be closely associated with the progression of Alzheimer's disease (AD), and these ...
Nadhim, Bayatti, Christian, Behl
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Regulation of corticotropin-releasing hormone in vitro
Peptides, 2001Studies examining regulation of corticotropin-releasing hormone (CRH) in vitro have been used to validate findings obtained in vivo and more importantly have been used as model systems to better understand signalling mechanisms responsible for the expression of the CRH gene and peptide.
M, Pisarska +4 more
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The Expression of Corticotropin‐Releasing Hormone in Melanoma
Pigment Cell Research, 2002We previously demonstrated that advanced melanoma cells express high amounts of proopiomelanocortin (POMC) that correlate with tumor progression. We now investigated whether the high expression of POMC derives from increased expression of corticotropin‐releasing hormone (CRH) and the possible role of CRH as a melanoma growth factor. Forty‐five cases of
Hirofumi, Sato +4 more
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The Rat Corticotropin‐releasing Hormone Genea
Annals of the New York Academy of Sciences, 1987In this paper we have described the isolation and characterization of the rat corticotropin releasing hormone gene. Nucleotide sequence comparisons with the human CRH gene have demonstrated several interesting regions of homology and suggest that the gene was highly conserved through evolution.
R C, Thompson +3 more
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