Results 11 to 20 of about 1,888 (176)

Development of CAR NK Cell Lines Selectively Targeting Cancer Cells Expressing Membrane Hsp70. [PDF]

MedComm (2020)
This work presents a novel CAR NK cell platform targeting membrane‐bound Hsp70, a tumor‐specific antigen broadly expressed on solid tumors but not on normal cells. Computational modeling confirmed strong binding between the CAR construct and the Hsp70‐derived TKD peptide.
Hachani K, Yazdi M, Carcopino C, Khademi Moghadam F, Smith MD, Trill A, Trefny MP, Hasanzadeh Kafshgari M, Hoch CC, Gaballa A, Alkotub B, Altomonte J, Pockley AG, Wagner E, Wollenberg B, Kobold S, Multhoff G, Bashiri Dezfouli A.   +17 more
europepmc   +2 more sources

Chronic lymphocytic leukemia with <i>IGH</i>::<i>BCL3</i>-translocation is characterized by a homogeneous and distinct genetic and epigenetic landscape. [PDF]

Hemasphere
Abstract Approximately 1% of chronic lymphocytic leukemia (CLL) cases harbor a translocation juxtaposing the immunoglobulin heavy chain (IGH) and B‐cell lymphoma 3 (BCL3) loci. Aiming at comprehensive molecular characterization of IGH::BCL3‐positive B‐cell neoplasms, we here investigated samples from 84 patients using fluorescence in situ hybridization
Drewes C, López C, Martinez-Manjón JE, Okeke N, Jebaraj B, Bens S, Brändl B, Dyer MJS, Eichhorst B, Fischer A, Fischer K, Robrecht S, Hallek M, Glaser S, Hillebrecht S, Jayne S, Kretzmer H, Mottok A, Müller FJ, Schneider C, Ammerpohl O, Del Val C, Stilgenbauer S, Tausch E, Siebert R.   +24 more
europepmc   +2 more sources

Real-world progression-free survival and overall survival in patients with HR⁺/HER2^- advanced breast cancer treated in first-line with ribociclib, endocrine monotherapy or chemotherapy: Results from the observational RIBANNA study. [PDF]

Int J Cancer
What's New? The CDK4/6 inhibitor ribociclib in combination with an endocrine‐based therapy has demonstrated significant progression‐free and overall survival benefits in patients with advanced/metastatic HR+/HER2‐ breast cancer in the pivotal MONALEESA trials.
Fasching PA, Brucker C, Decker T, Engel A, Göhler T, Jackisch C, Janssen J, Köhler A, Lüdtke-Heckenkamp K, Lüftner D, Marmé F, van Mackelenbergh M, Rautenberg B, Schmidt M, Weide R, Wimberger P, Kisseleff E, Pfister C, Quiering C, Roos C, Wöckel A.   +20 more
europepmc   +2 more sources

cosima-mango: Investigating Multi-Agent System robustness through integrated communication simulation

SoftwareX
Multi-Agent Systems (MAS) are implemented for numerous applications in Cyber-Physical Energy Systems (CPES). Before deploying these agent-based applications into the field, their functionalities must be tested to ensure robustness and reliability. Due to
Emilie Frost, Malin Radtke, Marvin Nebel-Wenner, Frauke Oest, Sanja Stark   +4 more
doaj   +1 more source

Machine Learning in Clinical Psychology and Psychotherapy Education: A Mixed Methods Pilot Survey of Postgraduate Students at a Swiss University

Frontiers in Public Health, 2021
Background: There is increasing use of psychotherapy apps in mental health care.Objective: This mixed methods pilot study aimed to explore postgraduate clinical psychology students' familiarity and formal exposure to topics related to artificial ...
Charlotte Blease, Anna Kharko, Marco Annoni, Marco Annoni, Jens Gaab, Cosima Locher, Cosima Locher, Cosima Locher   +7 more
doaj   +1 more source

Enhancing Language Inclusivity in Digital Humanities: Towards Sensitivity and Multilingualism: Includes interviews with Erzsébet Tóth-Czifra and Cosima Wagner

Modern Languages Open, 2021
Recently, multiple collaborative initiatives have been established which all aim to incorporate and enhance the representation of multilingualism into discussions on the otherwise largely English-dominated “field” of digital humanities.
Aliz Horvath
doaj   +1 more source

From Flybys to Sample Return: A Review of Space Probes and Robotic Sampling Technologies for Small Bodies

Journal of Field Robotics, EarlyView.
ABSTRACT As a crucial puzzle piece of deep space exploration, exploring small bodies can provide significant scientific insights and valuable mineral resources. Unlike missions to the Moon and Mars, small‐body missions pose distinct technical challenges, including communication delays, weak gravity, and uncertain environments. This paper reviews a full
Xin Zhang, Hao Zhou, Dalin Zhou, Zhaojie Ju   +3 more
wiley   +1 more source

Temperature dependence of yields of secondary organic aerosols from the ozonolysis of α-pinene and limonene [PDF]

Atmospheric Chemistry and Physics, 2009
Secondary organic aerosol (SOA) formation has been investigated as a function of temperature and humidity for the ozone-initiated reaction of the two monoterpenes α-pinene (243–313 K) and limonene (253–313 K) using the 84.5 m3 aerosol chamber AIDA.
R. Tillmann, Th. F. Mentel, A. Kiendler-Scharr, M. Hallquist, Å. M. Jonsson, O. Möhler, K.-H. Naumann, H. Saathoff, U. Schurath   +8 more
doaj  

Symphonic Gift: Wagner's Siegfried Idyll and the Hermeneutics of Sonata Form

Music Analysis, EarlyView.
ABSTRACT This article reimagines the place of programmatic interpretation within the New Formenlehre through the case study of Richard Wagner's Siegfried Idyll. To theorise the interaction between form and programme, I reconcile ‘separation’ and ‘conflation’ views – as represented by Julian Horton (2020) and Lawrence Kramer (2004a) – by deploying ...
RAFAEL ECHEVARRIA
wiley   +1 more source

Lack of Effects of the Presence of a Dog on Pain Perception in Healthy Participants—A Randomized Controlled Trial

Frontiers in Pain Research, 2021
Animal-assisted interventions (AAIs) have been shown to be effective in the treatment of pain. Studies suggest that relationships with animals can have comparable qualities to relationships with humans and that this enables animals to provide social ...
Cora Wagner, Jens Gaab, Cosima Locher, Cosima Locher, Cosima Locher, Karin Hediger, Karin Hediger, Karin Hediger, Karin Hediger   +8 more
doaj   +1 more source