Results 131 to 140 of about 17,777,046 (306)

DNA Methylation and Transcriptomic Profiles of Wilms Tumour Reveal New Deregulated Genes and Epigenetic Processes Relevant for Tumour Stratification and Management

open access: yesInternational Journal of Cancer, EarlyView.
ABSTRACT Wilms Tumour (WT), the most common kidney cancer in children, presents features of altered kidney development and frequently exhibits molecular alterations at the 11p15.5 imprinted locus, affecting the IGF2 and H19 genes, which contribute to tumour growth and predisposition.
Abu Saadat   +14 more
wiley   +1 more source

The Modified-Classroom Observation Schedule to Measure Intentional Communication (M-COSMIC): Evaluation of reliability and validity [PDF]

open access: yes, 2010
The Modified – Classroom Observation Schedule to Measure Intentional Communication (M-COSMIC) was developed as an ecologically valid measure of social-communication behaviour, delineating forms, functions, and intended partners of children’s spontaneous ...
Clifford, Sally   +6 more
core  

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

open access: yesInterdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li   +15 more
wiley   +1 more source

Cosmic Seed Theory: A New Model of Galactic Evolution [PDF]

open access: yes
Cosmic Seed Theory (CST) proposes a new cosmological framework in which localized galactic expansion events, triggered by the instability of supermassive black holes (Cosmic Seeds), replace the traditional model of a singular Big Bang. CST explains early
Cosmic Seed Foundation
core  

Weyl's principle, cosmic time and quantum fundamentalism [PDF]

open access: yes, 2010
We examine the necessary physical underpinnings for setting up the cosmological standard model with a global cosmic time parameter. In particular, we discuss the role of Weyl's principle which asserts that cosmic matter moves according to certain ...
Zinkernagel, Henrik, Rugh, Svend E.
core  

Towards Water, Food and Energy Security: The Global Challenges and Possible Solutions for a Holistic Vision of Sustainability

open access: yesIrrigation and Drainage, EarlyView.
ABSTRACT This invited paper gives an overview of the challenges the world is facing and offers a possible solution for water and food security within the holistic integrated concept of the water–energy–food (WEF) nexus. The paper summarizes the experience the author gained through working on various research projects at national and international ...
Ragab Ragab
wiley   +1 more source

Traces of Extra Dimensions in Cosmology [PDF]

open access: yes, 2010
In this thesis, we discuss the observational consequences of extra dimensions on cosmological phenomena. We begin with an overview of extra dimensions, from the initial ideas of Kaluza and Klein to the more recent concept of braneworld models and in ...
O'Callaghan, Eimear Eileen   +1 more
core  

DNA Extracted From Aged Formalin‐Fixed Paraffin‐Embedded Specimens of Patients With Papillary Thyroid Carcinomas Can Be Used for Whole Exome Sequencing

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
We aimed to assess the quality of DNA extracted from long‐term stored FFPE specimens of patients with papillary thyroid carcinoma from three hospitals in Hiroshima and their applicability to whole exome sequencing. FFPE samples preserved for up to 55 years may be amenable to sequencing with increased read depth.
Kousuke Tanimoto   +15 more
wiley   +1 more source

Estimating parameters of fluctuations in the cosmic microwave background [PDF]

open access: yes, 1995
We address questions that arise in statistical analyses of recently detected fluctuations in the Cosmic Microwave Background (CMB). Estimators of the quadrupole amplitude, Q, and spectral index, n, of the CMB angular fluctuation power spectrum are ...
Smoot, Georges   +2 more
core  

Humanism in the Age of Hyperreality: A Speculative Critique of AI Therapybots and the Neoliberal Commodification of Human Beings

open access: yesThe Journal of Humanistic Counseling, EarlyView.
ABSTRACT This article examines the future place of humanistic counseling, assuming the successful mass deployment of artificial intelligence therapy chatbots (AITCs). We systematically identify the limitations of AITCs through the lens of Jean Baudrillard's view on simulacra and hyperreality and identify five collective psychosocial consequences of ...
Brett. D. Wilkinson, Andrew M. Brown
wiley   +1 more source

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