Reframing Justice in Healthcare AI: An Ubuntu‐Based Approach for Africa
Developing World Bioethics, EarlyView.ABSTRACT There is an ongoing debate on how to balance the benefits and risks of artificial intelligence (AI), especially in healthcare. In resource‐constrained settings, such as Africa, where access to quality care remains a challenge, AI has the potential to improve efficiency, accessibility, and patient outcomes.
Aloysius Ochasi +3 more
wiley +1 more source
Global Geo-Pharmacogenomics: Environmental Mutational Signatures Drive Population-Level Heterogeneity in Anticancer Drug Response. [PDF]
J XenobiotJawahar J, James S.
europepmc +1 more source
Prescribing Trajectories in Type 2 Diabetes in the United States, 2019–2024
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Importance Clinical guidelines for type 2 diabetes (T2D) provide population‐level recommendations, but real‐world treatment patterns evolve dynamically and vary across patients. Understanding longitudinal prescribing trajectories may reveal heterogeneity in care not captured by cross‐sectional analyses.
Tobias S. Lux +14 more
wiley +1 more source
Increased and varied radiation during the Sun's encounters with cold clouds in the last 10 million years. [PDF]
Sci RepOpher M +9 more
europepmc +1 more source
Golden weapons and golden fetters: From the gold standard to the new geopolitics
The Economic History Review, EarlyView.Abstract This paper explores the historical relationship between monetary regimes, security concerns, and geopolitical tensions, particularly focusing on the role of gold. Throughout history, monetary systems have been deeply intertwined with international state systems and security provisions.
Harold James
wiley +1 more source
Synonymous and non-synonymous variants at splice junctions can disrupt splicing and are frequently linked to disease associated loss of function genes. [PDF]
BMC GenomicsSrinivasan S +6 more
europepmc +1 more source
Retrieving Your Concepts: Iris Murdoch on Original Sin
European Journal of Philosophy, EarlyView.Abstract In The Sovereignty of Good, Iris Murdoch argues that our moral thinking will be impoverished until it possesses a secular conception of original sin. Such a notion would need to remove unacceptable Christian baggage while retaining a genuine claim to be a descendant of the original Christian concept.
Samuel Filby
wiley +1 more source
Unraveling the active site cover of coproheme decarboxylase from Listeria monocytogenes
The FEBS Journal, EarlyView.During heme biosynthesis in Gram‐positive bacteria, coproheme decarboxylase (ChdC) catalyzes the conversion of four‐propionate substrate coproheme to the two propionate product heme b. Its active site is universally covered by a flexible linking loop. This study identifies an important histidine residue, which stabilizes the loop in a ChdC homolog.
Nikolaus Falb +4 more
wiley +1 more source
SigRescueR: a pan-system framework for noise correction and mutational signature identification across sequencing platforms. [PDF]
Brief BioinformNguyen PT, Zhivagui M.
europepmc +1 more source
The Heythrop Journal, EarlyView.Abstract In this essay I contend that, whatever one might say about F.W.J. Schelling's historical and conceptual influence on Paul Tillich's doctrines, the overall style of Tillich's project can helpfully be dubbed Schellingian to the extent it mixes together discourses, genres, and vocabularies into an ever‐expanding whole. To the extent that anything
Daniel Whistler
wiley +1 more source