Results 191 to 200 of about 102,940,073 (295)

ABSTRACTS

Precision Radiation Oncology, EarlyView.
wiley   +1 more source

Distinct clinical and genetic characteristics of myelodysplastic syndrome in younger patients

British Journal of Haematology, EarlyView.
Summary Myelodysplastic neoplasms (formerly myelodysplastic syndromes, MDS) are heterogeneous clonal haematological malignancies that primarily affect the elderly, though a notable proportion of patients are diagnosed at younger ages. We retrospectively analysed 1437 patients diagnosed or treated at Asan Medical Center between 1989 and 2022, comparing ...
Hyunkyung Park, Eun‐Ji Choi, Young‐Uk Cho, Yunsuk Choi, Han‐Seung Park, Jung‐Hee Lee, Joon Young Hur, Jisu Jeong, Seungah Cha, Yueun Lee, Young‐Shin Lee, Young‐Ah Kang, Mijin Jeon, Ji Min Woo, Hyeran Kang, Je‐Hwan Lee   +15 more
wiley   +1 more source

Prior therapy defines mutation profiles in childhood cancer at relapse. [PDF]

Nature
Layeghifard M, Díaz-Gay M, Bergstrom EN, Mahendralingam MJ, Light N, Blay S, Nash JO, Anderson ND, Au JN, Davidson S, Ballester PL, Wen T, Daud SK, Edward LM, Ashiqul Islam SM, Khandekar A, Otlu B, Brunga L, Hammad R, Nassif S, Thacker NH, Feltham T, Fuentes-Bolanos NA, Wong-Erasmus M, Levine MF, Miller KE, Shukla NN, Kinnaman MD, Glodzik D, Portwine C, Millson S, Zorzi AP, Mikhail M, Fernandez CV, Wheaton L, Gundem G, Kung AL, Tabori U, Mayoh C, Papaemmanuil E, Cowley MJ, Malkin D, Villani A, Alexandrov LB, Shlien A.   +44 more
europepmc   +1 more source

Whole‐genome and transcriptome analysis in relapsed/refractory non‐Hodgkin lymphoma: Results from a multicentre precision oncology cohort

British Journal of Haematology, EarlyView.
Summary Comprehensive genome and transcriptome profiling can inform the diagnosis, prognosis and management of relapsed/refractory (R/R) solid malignancies, yet its integration into clinical care has lagged despite strong biological rationale. We evaluated the clinical utility of whole genome and transcriptome analysis (WGTA) in 65 patients (37 ...
Kathleen Wee, Eric J. Zhao, Cassidy Clemente‐Jones, Rebecca J. Deyell, Shahrad R. Rassekh, Anita Villani, Rosemarie Venier, Daniel Sinnett, Sylvie Langlois, Thai Hoa Tran, Thomas Sontag, Stephanie Grover, Scott Davidson, Nisha Kanwar, Winnie Lo, Erin Pleasance, Laura Williamson, Yaoqing Shen, Alina S. Gerrie, Kerry J. Savage, Laurie H. Sehn, Christopher P. Venner, Marco A. Marra, Janessa Laskin, Diego Villa   +24 more
wiley   +1 more source

Somatic likelihood tiering: an interpretable post-calling triage protocol for tumor-only whole-exome variant review. [PDF]

Brief Bioinform
Stawiski K, Kamran SC, Perera-Bel J, Lee J, Bellmunt J, Mouw KW, De Carvalho FLF.   +6 more
europepmc   +1 more source

Refining the timing of Middle Pleistocene (MIS 12 to MIS 6) ice advances into northern central Europe: sedimentological analysis and single‐grain luminescence dating of glaciotectonic complexes and tunnel‐valley fills

Boreas, EarlyView.
We summarize the current state of knowledge on the age of the Middle Pleistocene ice advances into northern central Europe and provide 25 new single‐grain feldspar luminescence ages of Elsterian and Saalian glacigenic sediments to constrain the age of the ice advances and their tentative correlation with marine isotope stages/substages.
Niklas von Soest, Neda Rahimzadeh, Debra Colarossi, Falko Malis, Tobias Lauer, Wera Sander‐Beuermann, Yvonne Spychala, Christian Brandes, Runa Fälber, Sumiko Tsukamoto, Jutta Winsemann   +10 more
wiley   +1 more source

Etiology-guided mutational signature learning from DNA repair knockouts in cell lines using supervised NMF. [PDF]

NAR Genom Bioinform
Goossens S, Tepeli YI, Seale C, Gonçalves JP.   +3 more
europepmc   +1 more source

A bifacial paradise—The site of Ochtmissen, Germany, and its lithic assemblage in the context of the last glacial (early MIS 4) in the north‐central European Lowland

Boreas, EarlyView.
The Palaeolithic site of Ochtmissen (Lower Saxony, Germany) was excavated in fluvial terrace deposits during the winter of 1993/1994. The current study presents, for the first time, a thorough analysis of the lithic assemblage, encompassing its primary technological and typological characteristics, as well as the type and age of the fluvial deposits ...
Gianpiero Di Maida, Jutta Winsemann, Markus Fuchs, Niklas von Soest, Thomas Terberger   +4 more
wiley   +1 more source

Robust discovery of mutational signatures using power posteriors. [PDF]

PLoS Comput Biol
Xue C, Miller JW, Carter SL, Huggins JH.
europepmc   +1 more source

PTEN homozygous deletion is a negative prognostic factor in tumor treating fields‐treated glioblastoma, IDH wildtype patients

Brain Pathology, EarlyView.
In a molecularly confirmed cohort of 64 newly diagnosed, TTFields‐treated glioblastomas, IDH‐wildtype, homozygous PTEN deletion was associated with markedly shorter overall survival (368 vs. 603 days) and remained an independent adverse prognostic factor.
Jakob Nückles, Claudius Jelgersma, Christin Siewert, Brendan Osberg, Simone Schmid, Arend Koch, Eilís Perez, Daniel Teichmann, Martin Misch, Anna‐Gila Karbe, Susanne Ukrow, Patrick N. Harter, Ruth M. Stassart, Peter Vajkoczy, Julia Onken, David Capper   +15 more
wiley   +1 more source