Results 21 to 30 of about 35,666 (219)
The Astrophysical Journal, 2023 We present the first statistical sample of faint type 1 AGNs at z > 4 identified by JWST/NIRSpec deep spectroscopy. Among the 185 galaxies at z _spec = 3.8–8.9 confirmed with NIRSpec, our systematic search for broad-line emission reveals 10 type 1 AGNs ...
Yuichi Harikane +8 more
doaj +1 more source
The Astrophysical Journal, 2023 HESS J1702-420 is a multi-TeV gamma-ray source with an unusual energy-dependent morphology. The recent H.E.S.S. observations suggest that the emission is well described by a combination of the point-like HESS J1702-420A (dominating at highest energies ...
Felix Aharonian +2 more
doaj +1 more source
Proteogenomic characterization of cholangiocarcinoma
Hepatology, EarlyView., 2022 Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng +18 more
wiley +1 more source
Journal of Space Weather and Space ClimateThis study’s objective is to better specify the rare occurrence of super equatorial plasma bubbles in particular to the European longitude sector, detailing their spatio-temporal evolution, and better understanding pre-conditions for their development ...
Zakharenkova Irina +6 more
doaj +1 more source
Assessment of Accuracy of COSMIC and KOMPSAT Radio Occultation Temperature and Pressure [PDF]
E3S Web of ConferencesRadio Occultation is a technique used by orbiting satellites to measure planetary atmosphere properties like temperature, pressure, and water vapor.
Descalzo Karl Philippe A. +1 more
doaj +1 more source
Ionospheric Variability during the 2020–2021 SSW: COSMIC-2 Observations and WACCM-X Simulations
Atmosphere, 2022 Variability in the ionosphere during the 2020–2021 sudden stratospheric warming (SSW) is investigated using a combination of Constellation Observing System for Meteorology, Ionosphere, and Climate-2 (COSMIC-2) observations and the Whole Atmosphere ...
Nicholas Pedatella
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Validation of COSMIC-2-Derived Ionospheric Peak Parameters Using Measurements of Ionosondes
Remote Sensing, 2021 Although numerous validations for the ionospheric peak parameters values (IPPVs) obtained from the Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC) have been conducted using ionosonde measurements as a reference ...
Shuangshuang Shi +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source