Results 161 to 170 of about 277,677 (243)

Natural Language Processing for Analyzing Electronic Health Records and Clinical Notes in Cancer Research: A Review [PDF]

Objective: This review aims to analyze the application of natural language processing (NLP) techniques in cancer research using electronic health records (EHRs) and clinical notes. This review addresses gaps in the existing literature by providing a broader perspective than previous studies focused on specific cancer types or applications.
arxiv   +1 more source

A systematic review of electron FLASH dosimetry and beam control mechanisms utilized with modified non‐clinical LINACs

Journal of Applied Clinical Medical Physics, Volume 26, Issue 4, April 2025.
Abstract Background FLASH has been shown to spare normal tissue toxicity while maintaining tumor control. However, existing irradiation platforms and dosimetry are not compatible. Consequently, an abundance of FLASH delivery devices and new dosimetry across all modalities has been created.
Justin DeFrancisco, Siyong Kim
wiley   +1 more source

Enhancer RNA Transcriptome‐Wide Association Study Reveals a Distinctive Class of Pan‐Cancer Susceptibility eRNAs

Advanced Science, Volume 12, Issue 13, April 3, 2025.
Enhancer RNA (eRNA) can play a key role in cancer initiation and progression. Here, the authors conducts a comprehensive pan‐cancer eRNA‐based TWAS analysis and discovered a distinct class of eRNA‐mediated cancer susceptibility genes across 23 cancer types.
Wenyan Chen, Zeyang Wang, Yinuo Wang, Jianxiang Lin, Shuxin Chen, Hui Chen, Xuelian Ma, Xudong Zou, Xing Li, Yangmei Qin, Kewei Xiong, Xixian Ma, Qi Liao, Yunbo Qiao, Lei Li   +14 more
wiley   +1 more source

Whole Exome Sequencing Study Identifies Distinct Characteristics of Transformed Small Cell Lung Cancer With EGFR Mutation Compared to De Novo Small Cell and Primary Non‐Small Cell Lung Cancers

Cancer Medicine, Volume 14, Issue 7, April 2025.
ABSTRACT Background Epidermal growth factor receptor (EGFR)‐mutated lung adenocarcinoma (LUAD) is the most common subtype among non‐small cell lung cancer (NSCLC) and targeted therapies are the primary approach for treatment. However, the development of resistance to therapy and histological transformation into small cell lung cancer (SCLC) present ...
Jinjing Tan, Dan Zhao, Qunhui Wang, Yanjing Peng, Jie Li, Xi Li, Nanying Che, Ying Hu, Hua Zheng   +8 more
wiley   +1 more source

Integrated genomic and transcriptomic analyses of radiation-induced malignancies [PDF]

, 2016
Cancer is a genetic disease caused by an unregulated expansion of a clone of cells (Sompayrac, 2004). The genetic abnormalities in cancer are the consequences of defective DNA replication, repair, maintenance, and modification, genetic background, and ...
Lee, Yong Eun
core   +1 more source

Sam-Sam Association Between EphA2 and SASH1: In Silico Studies of Cancer-Linked Mutations

Molecules
Recently, SASH1 has emerged as a novel protein interactor of a few Eph tyrosine kinase receptors like EphA2. These interactions involve the first N-terminal Sam (sterile alpha motif) domain of SASH1 (SASH1-Sam1) and the Sam domain of Eph receptors ...
Marian Vincenzi, Flavia Anna Mercurio, Ida Autiero, Marilisa Leone   +3 more
doaj   +1 more source

Profiling PIK3CA variants in disorders of somatic mosaicism

Genetics in Medicine Open, 2023
Purpose: Variants in PIK3CA (encoding p110α; the catalytic subunit of PI3K) characterize some disorders of somatic mosaicism (DoSM) conditions with clinical features, including sporadic overgrowth and vascular malformations.
Bahareh A. Mojarad, Patricia V. Hernandez, Michael J. Evenson, Meagan M. Corliss, Sarah L. Stein, Amy Theos, Carrie C. Coughlin, Bryan Sisk, Maithilee Menezes, Molly C. Schroeder, Jonathan W. Heusel, Julie A. Neidich, Yang Cao   +12 more
doaj  

Circulating Tumour DNA in Patients With EGFR‐Mutated Non‐Small‐Cell Lung Cancer and Early Disease Progression After First‐Line Osimertinib Treatment: The ELUCIDATOR Multicentre Prospective Observational Study

Cancer Medicine, Volume 14, Issue 7, April 2025.
ABSTRACT Background Osimertinib is the standard therapy for patients with chemotherapy‐naive advanced non‐small‐cell lung cancer (NSCLC) harbouring sensitising epidermal growth factor receptor (EGFR) mutations. However, some patients treated with osimertinib experience progressive disease (PD).
Akihiro Tamiya, Yasuyuki Mizumori, Mitsuo Osuga, Shun‐ichi Isa, Yoshihiko Taniguchi, Keiichi Nakamura, Daijiro Harada, Tsutomu Shinohara, Hidetoshi Yanai, Katsumi Nakatomi, Masahide Oki, Masahide Mori, Tomohito Kuwako, Koji Yamazaki, Atsuhisa Tamura, Masahiko Ando, Yasuhiro Koh   +16 more
wiley   +1 more source

Does the worsening galactic cosmic radiation environment observed by CRaTER preclude future manned deep space exploration? [PDF]

, 2014
The Sun and its solar wind are currently exhibiting extremely low densities and magnetic field strengths, representing states that have never been observed during the space age.
Blake, J. B., Case, Anthony, Joyce, Colin J., Kasper, Justin, Mazur, J. E., Petro, N., Porter, Jamie A., Quinn, M., Schwadron, Nathan A., Smith, Charles W., Smith, Sonya S., Spence, Harlan E., Townsend, Lawrence W., Turner, R., Wilson, Jody K., Zeitlin, Cary   +15 more
core   +1 more source

The Phenolic Signature of Psidium cattleianum Fruits and Leaves Modulates TRPV1 and TRPA1 Transient Receptor Potential Channels: A Metabolomics, In Vitro, and In Silico Study

Food Science &Nutrition, Volume 13, Issue 4, April 2025.
An untargeted metabolomics study was performed to find the encompassed phytochemicals in the fruit and leaf extract of Psidium cattleianum. This enabled the annotation of 469 compounds belonging to different phenolic subclasses, with a predominance of flavonoids and phenolics.
Leilei Zhang, Fabio Arturo Iannotti, Fatema R. Saber, Reem K. Arafa, Aniello Schiano Moriello, Rasha A. Rasle, Anton Soria‐Lopez, Sara G. Abd EL‐Gawwad, Gabriele Rocchetti, Paz Otero, Łukasz Kulinowski, Krystyna Skalicka‐Woźniak, Luigi Lucini, Jesus Simal‐Gandara   +13 more
wiley   +1 more source