Results 171 to 180 of about 184,107 (180)

Abstract 5062: Evaluation of genetic mutations in non-small cell lung cancer patients

Cancer Research
Lung cancers represent the second most common cancer and Non-Small Cell Lung Cancer (NSCLC) constitutes 80-85% of all lung cancers. Genes within several cellular pathways have been previously evaluated for their clinical impact in NSCLC.
Miles Rothstein, Phillip Broughton, Ella G Markalunas, Avery T. Funkhouser, Lorie Allen, Julie C. Martin, W. Edenfield, Anna V. Blenda   +7 more
semanticscholar   +1 more source

TGDD: A Genomics-Based Database for Tumor Treatment Drugs

iCell
With advancements in cancer genomics, precision medicine is increasingly being applied in cancer treatment. However, the fragmentation of genetic mutation-related information and the lack of standardized interpretation tools present significant ...
Wen Li, Zhining Xiong, Kangming He, Zhining Zhang, Huilin Wei, Qiuxia Meng, Tengyue Yan, Yuxiao He, Xuanyu Pan, Yanling Hu   +9 more
semanticscholar   +1 more source

Autophagy promotes the acquisition of genotoxic resistance in cancer cells in a paracrine manner via upregulation of PLK1-RAD9A axis.

Journal of Biochemistry (Tokyo)
Autophagy suppresses tumorigenesis in normal cells, but in established tumors, it can promote tumor progression, particularly by enhancing resistance to stress. However, the mechanism underlying this tumor-promoting function remains unclear.
M. Ikura, Takuma Shiraki, T. Ikura, Kanji Furuya   +3 more
semanticscholar   +1 more source

An integrative analysis of ASCL1 in breast cancer and inhibition of ASCL1 increases paclitaxel sensitivity by activating ferroptosis via the CREB1/GPX4 axis

Frontiers in Immunology
Objective Our previous study found that Achaete-scute complex homolog 1 (ASCL1) is involved in classifying BC subtypes with different prognostic and pathological characteristics.
Xiaolu Yang, Yilu Li, Yaqi Peng, Yuan Chang, Binglu He, Tianqi Zhang, Shiyu Zhang, Cuizhi Geng, Yunjiang Liu, Xiaolong Li, Jun Hao, Li Ma   +11 more
semanticscholar   +1 more source

A Cancer Treatment Plan Recommendation System Based on Whole Genome Sequencing Data of Cancer Tissues *

Systems and Information Engineering Design Symposium
With the continuous development of gene sequencing technology, new targets for cancer treatment are constantly being discovered. To help oncologists develop corresponding treatment plans based on the results of gene sequencing of cancer tissues, this ...
Andrew Zheng, Wenqiang Chen, Bin Li
semanticscholar   +1 more source

COSMIC: High‐Resolution Cancer Genetics Using the Catalogue of Somatic Mutations in Cancer

Current Protocols in Human Genetics, 2016
S. Forbes, D. Beare, Nidhi Bindal, S. Bamford, Sari Ward, C. Cole, Mingming Jia, C. Kok, Harry Boutselakis, Tisham De, Zbyslaw Sondka, Laura Ponting, Raymund Stefancsik, Bhavana Harsha, J. Tate, E. Dawson, Sam L. Thompson, Harry C Jubb, P. Campbell   +18 more
semanticscholar   +1 more source

Abstract 2599: COSMIC Cancer Gene Census: expert descriptions across genes in oncogenesis

, 2017
Zbyslaw Sondka, S. Bamford, C. Cole, E. Dawson, Laura Ponting, Raymund Stefancsik, Sari Ward, J. Tate, P. Campbell, S. Forbes   +9 more
semanticscholar   +1 more source

DNAJC9 expression in basal-like and luminal A breast cancer subtypes predicts worse survival

Molecular Biology Reports, 2023
Oya Incekara, T. Acun
semanticscholar   +1 more source

COSMIC (Catalogue of Somatic Mutations in Cancer)

, 2014
M. Griffith, O. Griffith
semanticscholar   +1 more source

Table 5. [Common Cancer-Related PIK3CA Mutations Reported in COSMIC Database].

, 2013
Ghayda Mirzaa, Robert L. Conway, John M. Graham, William B. Dobyns   +3 more
openalex