Results 191 to 200 of about 194,869 (207)

Study on the changes of somatic mutation in colorectal metastatic cancer based on COSMIC database

, 2019
Objective To screen the significant differences in somatic gene mutations between primary colorectal cancer and colorectal metastatic cancer using the Catalogue of Somatic Mutations In Cancer Catalog (COSMIC) Database and analyze its possible functions ...
Zhengchun Kang, E Jifu, Liangliang Zhu, Feihu Yan   +3 more
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Abstract 4312: Identification of shared mutations across many parallel human and canine cancers based on comprehensive survey of canine cancer mutations and the “caninization” of human mutations from COSMIC

Cancer Research, 2023
Introduction: Vidium Insight™ is a canine cancer genomic biomarker database built from exhaustive curation of peer-reviewed literature describing genomic mutations in canine cancers.
Sharadha Sakthikumar, Salvatore J. Facista, Derick Whitley, Manisha Warrier, William P. D. Hendricks, Guannan Wang   +5 more
semanticscholar   +1 more source

Standing in the canine precision medicine knowledge gap: Improving annotation of canine cancer genomic biomarkers through systematic comparative analysis of human cancer mutations in COSMIC.

Veterinary and Comparative Oncology, 2023
The accrual of cancer mutation data and related functional and clinical associations have revolutionised human oncology, enabling the advancement of precision medicine and biomarker-guided clinical management.
Sharadha Sakthikumar, Salvatore J. Facista, Derick Whitley, S. Byron, Zeeshan Ahmed, Manisha Warrier, Zhanyang Zhu, Esther Chon, Kathryn Banovich, David Haworth, William P. D. Hendricks, Guannan Wang   +11 more
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Abstract 5028: Integration of molecular data into cancer patient database

Cancer Research, 2022
Background: Precision medicine holds promise of being a more effective method for treating complex diseases such as cancer. Nuanced care is needed, as the development and clinical course of cancer is multifactorial with influences from the general ...
Basil H. Chaballout, Avery T. Funkhouser, Bailey B Blair, Jane Goodwin, Alexander M Strigenz, C. Arthur, Julie C. Martin, W. Edenfield, Anna V. Blenda   +8 more
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Abstract 3143: A bioinformatic pipeline for identifying change-of-metabolic-function cancer mutations

Cancer Research, 2023
Cancer arises through clonal evolution, in some cases selecting change of metabolic function (COMF) mutations that functionally alter proteins to affect cellular metabolism.
Kevin J. Tu, B. Diplas, Joshua A Regal, Matthew S. Waitkus, Christopher J. Pirozzi, Zachary J. Reitman   +5 more
semanticscholar   +1 more source

Abstract 906: COSMIC: Describing the world’s knowledge of somatic mutations in cancer

Bioinformatics, Convergence Science, and Systems Biology, 2019
COSMIC, the Catalogue Of Somatic Mutations In Cancer (http://cancer.sanger.ac.uk/cosmic) is a continual effort to integrate all available information on somatic mutations and other molecular alterations causing every form of human cancer. Being the world’
S. Forbes, D. Beare, charalampos boutselakis, S. Bamford, Kate Noble, Claire E. Rye, J. Tate, C. Kok, Charlie Hathaway, Laura Ponting, Chris Ramshaw, R. Stefancsik, Sam L. Thompson, Bhavana Harsha, Nidhi Bindal, Shicai Wang, S. Jupe, H. Speedy, C. Creatore, Peter Fish, Sari Ward, C. Cole, E. Dawson, Zbyslaw Sondka   +23 more
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Abstract 2599: COSMIC Cancer Gene Census: expert descriptions across genes in oncogenesis

, 2017
The Cancer Gene Census is an ongoing effort to catalogue genes for which somatic mutations have been causally implicated in cancer. The Census comprises manually curated summaries of the most relevant information for cancer-driving genes and their ...
Zbyslaw Sondka, S. Bamford, C. Cole, E. Dawson, Laura Ponting, R. Stefancsik, Sari Ward, J. Tate, P. Campbell, S. Forbes   +9 more
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COSMIC (Catalogue of Somatic Mutations in Cancer)

, 2014
Description: Database to store and display somatic mutation information and related details and contains information relating to human cancers. The mutation data and associated information is extracted from the primary literature.
M. Griffith, O. Griffith
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CDH1 gene as biomarker towards breast cancer prediction.

Journal of Biomolecular Structure and Dynamics
Breast cancer is considered to be happened due to genetic aberration. Out of several genes expressed, it is found that cadherin 1, type 1 (CDH1) is responsible in several ways to control the metabolic order in human.
Srijan Banerjee, Antara Sengupta, S. Ghosh, Raja Banerjee   +3 more
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TGDD: A Genomics-Based Database for Tumor Treatment Drugs

iCell
With advancements in cancer genomics, precision medicine is increasingly being applied in cancer treatment. However, the fragmentation of genetic mutation-related information and the lack of standardized interpretation tools present significant ...
Wen Li, Zhining Xiong, Kangming He, Zhining Zhang, Huilin Wei, Qiuxia Meng, Tengyue Yan, Yuxiao He, Xuanyu Pan, Yanling Hu   +9 more
semanticscholar   +1 more source