Results 221 to 230 of about 263,873 (299)

Germline pathogenic variants in HIC1 DNA binding domains are associated with familial serrated polyposis syndrome

open access: yesInternational Journal of Cancer, Volume 157, Issue 6, Page 1154-1167, 15 September 2025.
What's new? Serrated polyposis syndrome has been associated with an increased risk of colorectal cancer. HIC1 is a tumor suppressor gene commonly silenced in serrated polyps and several cancers. This study suggests HIC1 as a novel germline predisposition factor to serrated polyposis syndrome, with variants altering gene transcriptional regulation and ...
Xavier Domínguez‐Rovira   +24 more
wiley   +1 more source

Analysis of IDH1 and IDH2 mutations as causes of the hypermethylator phenotype in colorectal cancer

open access: yesThe Journal of Pathology, Volume 267, Issue 1, Page 40-55, September 2025.
Abstract The CpG island methylator phenotype (CIMP) occurs in many colorectal cancers (CRCs). CIMP is closely associated with global hypermethylation and tends to occur in proximal tumours with microsatellite instability (MSI), but its origins have been obscure.
Joseph C Ward   +59 more
wiley   +1 more source

Cosmic-ray-induced correlated errors in superconducting qubit array. [PDF]

open access: yesNat Commun
Li X   +17 more
europepmc   +1 more source

Revolutionizing Veterinary Medicine: The Role of Nanoparticles in Advancing Animal Health, Nutrition and Disease Management

open access: yesVeterinary Medicine and Science, Volume 11, Issue 5, September 2025.
Nanoparticles are transforming animal care by enhancing nutrition, drug delivery and disease prevention. This study highlights their role in improving nutrient absorption in livestock, facilitating targeted drug delivery and boosting vaccine efficacy. Additionally, nanoparticles effectively reduce harmful mycotoxins in animal feeds, promoting overall ...
Mohsen Kazemi
wiley   +1 more source

Cosmic Ray Irradiation of Interstellar Ices on Sulfur-Rich Grains: A Possible Source of Sulfur-Bearing Molecules. [PDF]

open access: yesACS Earth Space Chem
Mifsud DV   +15 more
europepmc   +1 more source

A Guide to Machine Learning Epistemic Ignorance, Hidden Paradoxes, and Other Tensions

open access: yesWIREs Data Mining and Knowledge Discovery, Volume 15, Issue 3, September 2025.
ABSTRACT Machine learning (ML) has rapidly scaled in capacity and complexity, yet blind spots persist beneath its high performance façade. In order to shed more light on this argument, this paper presents a curated catalogue of 175 unconventional concepts, each capturing a paradox, tension, or overlooked risk in modern ML practice.
M. Z. Naser
wiley   +1 more source

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