Results 91 to 100 of about 340,792 (285)

Efficacy and Safety of Guselkumab in Participants with Active Psoriatic Arthritis After Inadequate Response to One Prior Tumor Necrosis Factor Inhibitor: Week‐24 Results of the Phase 3, Randomized, Placebo‐Controlled SOLSTICE Study

Arthritis &Rheumatology, Accepted Article.
Objective Evaluate the efficacy and safety of guselkumab, an interleukin‐23p19‐subunit inhibitor, in participants with active psoriatic arthritis (PsA) and inadequate response (inadequate efficacy and/or intolerance) to one prior tumor necrosis factor inhibitor (TNFi‐IR).
Alexis Ogdie, Joseph F Merola, Philip J Mease, Christopher T Ritchlin, Jose U Scher, Kimberly Parnell Lafferty, Daphne Chan, Soumya D Chakravarty, Wayne Langholff, Yanli Wang, Jie Shao, Yevgeniy Krol, Alice B Gottlieb   +12 more
wiley   +1 more source

Cosmic jurisdictions: quod lege naturae, moribus et consuetudine inductum est

Науковий вісник Ужгородського національного університету. Серія Право
The study is devoted to organizing the legal space of the Universe based on “ius naturale,” morals, and consuetudes of space activities, with the prospects for the existence of extraterrestrial intelligent beings in the Universe.
M. I. Myklush, V. K. Marinich
doaj   +1 more source

The THESEUS Space Mission and the Infrared Telescope Calibration Unit

Astronomische Nachrichten, EarlyView.
ABSTRACT The Transient High‐Energy Sky and Early Universe Surveyor (THESEUS) is an ESA M7 mission concept currently in Phase A, designed to exploit gamma‐ray bursts to probe the early Universe while advancing multi‐messenger and time‐domain astrophysics. To achieve its ambitious goals, THESEUS will combine wide‐band x‐ray and gamma‐ray monitors with an
András Péter Joó, Rebeka Gyöngyi Kiss, Lorenzo Amati, Bendegúz Koncz, Örs Detre, Gyula Zilizi, Zsolt Bagoly, István I. Rácz, Sándor Pintér, L. Viktor Tóth   +9 more
wiley   +1 more source

No-Bang Quantum State of the Cosmos

, 2008
A quantum state of the entire cosmos (universe or multiverse) is proposed which is the equal mixture of the Giddings-Marolf states that are asymptotically single de Sitter spacetimes in both past and future and are regular on the throat or neck of ...
Ashok S, Banks T, Banks T, Banks T, Banks T, Banks T, Banks T, Bousso R, Bousso R, Bousso R, Carlip S, Carr B J, Davies P C W, Denef F, Denef F, Deutsch D, Don N Page, Douglas M R, Douglas M R, Douglas M R, Douglas M R, Dyson F, Dyson L, Fischler W, Freedman W L, Garriga J, Gell-Mann M, Goheer N, Halliwell J J, Hartle J B Hawking S W Hertog T, Hartle J B Hawking S W Hertog T, Hawking S W, Hawking S W, Hawking S W, Hawking S W, Hawking S W Turok N G, James W, James W, Kottler F, Leslie J, Liddle A R, Linde A, Linde A, Linde A D, Linde A D, Linde A D, Linde A D, Linde A D, Linde A D, Linde A D, Linde A D, Lodge O, McInnes B, Nariai H, Page D N, Page D N, Page D N, Page D N, Page D N, Page D N, Page D N, Page D N, Page D N Gibbons G W Shellard E P S Rankin S J, Penrose R, Penrose R, Perlmutter S, Perlmutter S, Rees M J, Riess A G, Riess A G, Riess A G, Spergel D N, Spergel D N, Starobinsky A A, Susskind L, Susskind L, Susskind L, Tolman R C, Tonry J L, Vilenkin A, Vilenkin A, Vilenkin A, Vilenkin A, Vilenkin A, Vilenkin A, Vilenkin A, Vilenkin A Gibbons G W Shellard E P S Rankin S J, Yao W-M, Zel'dovich Ya B, Zel'dovich Ya B   +89 more
core   +3 more sources

Hidden No More: Spotlight on Tidal Disruption Events in Active Galactic Nuclei

Astronomische Nachrichten, EarlyView.
ABSTRACT Tidal disruption events (TDEs) are typically discovered in previously quiescent galaxies. However, earlier studies have revealed a handful of TDEs occurring in pre‐existing active galactic nuclei (AGN). We discuss AT2019aalc, a promising TDE candidate in an AGN, and compare it to similar sources.
Patrik Milán Veres
wiley   +1 more source

Making it explicit – Sustained shared thinking dialogue as a way to explore children's perspectives on quality in German early childhood education and care

British Educational Research Journal, EarlyView.
Abstract To negotiate quality in early childhood education and care, we must ask from different perspectives what constitutes a good centre for children. The children themselves have only recently been identified as a resource to contribute to that discussion.
Katrin Macha, Frauke Hildebrandt, Caroline Wronski, Jan Lonnemann, Mathias Urban   +4 more
wiley   +1 more source

Metric Expansion from Microscopic Dynamics in an Inhomogeneous Universe

, 2010
Theories with ingredients like the Higgs mechanism, gravitons, and inflaton fields rejuvenate the idea that relativistic kinematics is dynamically emergent. Eternal inflation treats the Hubble constant H as depending on location.
Bonnor W B, Brax P, Fahr H J, Frank C F, Hooft G 't, Khoury J, Page D N, Sakharov A, Sanders R H, Sascha Vongehr, Steinhardt P J, Volovik G E   +11 more
core   +1 more source

Development of Raman Spectroscopy and Machine Learning Methods for Protein Aggregate Quantification: Application to BSA in Chromatographic Processes

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Protein aggregation poses a significant risk to biopharmaceutical product quality, as even minor amounts of oligomeric species can compromise efficacy and safety. Rapid and reliable detection of protein aggregates thus remains a major challenge in biopharmaceutical manufacturing.
Jakob Heyer‐Müller, Robin Schiemer, Lars Robbel, Michael Schmitt, Jürgen Hubbuch   +4 more
wiley   +1 more source

Innovative methodology for flexible monitoring of various bioprocesses by using pre‐existing Raman data coupled with automated transfer learning technique

Biotechnology Progress, EarlyView.
The application of the transfer learning algorithm successfully allowed the use of a model built on process A for real‐time monitoring of process B. This study shows the improvement obtained with this methodology compared to the direct application of the model.
Adèle Schini, Hadi El Radi, Johan Cailletaud, Célia Sanchez, Nathan Gay, Bruno Ebel, Emmanuel Guedon, Laurent Jourdainne   +7 more
wiley   +1 more source

Improving Antioxidants and Physicochemical Properties of Wild Rice Noodles by Fortification With Carrot Powder

Cereal Chemistry, EarlyView.
ABSTRACT Background and Objectives Wild rice (WR), a nutritious cereal rich in phytochemicals, remains underutilized despite its health benefits. This study explored deep purple (DP), purple sun hybrid (PSH), purple haze (PH), cosmic purple (CP), and vistaric sky blue (VSB) carrot powders as fortificants in WR noodles at 10%, 20%, and 30% levels in ...
Beverly Cheruto Too, Daniel Zogona, Daniela Herrera Balandrano, Trust Beta   +3 more
wiley   +1 more source