Results 71 to 80 of about 22,622,352 (340)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Analysis-suitable T-splines: characterization, refineability, and approximation [PDF]

Mathematical Models and Methods in Applied Sciences,Vol. 24, No. 06, pp. 1141-1164 (2014), 2012
We establish several fundamental properties of analysis-suitable T-splines which are important for design and analysis. First, we characterize T-spline spaces and prove that the space of smooth bicubic polynomials, defined over the extended T-mesh of an analysis-suitable T-spline, is contained in the corresponding analysis-suitable T-spline space. This
arxiv  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Preprint Big City 3D Visual Analysis [PDF]

arXiv, 2015
This is the preprint version of our paper on EUROGRAPHICS 2015. A big city visual analysis platform based on Web Virtual Reality Geographical Information System (WEBVRGIS) is presented. Extensive model editing functions and spatial analysis functions are available, including terrain analysis, spatial analysis, sunlight analysis, traffic analysis ...
arxiv  

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source

A proposed solution for analysis management in high energy physics [PDF]

arXiv, 2018
This paper presents an architecture for the analysis management in high energy physics experiments. Some new concepts on data analysis are introduced. A protocol for organizing and operating an analysis is raised. A toolkit following this architecture is developed, which provides a solution of analysis management with both flexibility and ...
arxiv  

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Alkane biosynthesis gene expression and its increased production in recombinant cyanobacteria

FEBS Open Bio, EarlyView.
The transcription and mRNA structures of the alkane biosynthesis genes ado/aar were analysed in the representative cyanobacteria PCC 6803 and SK1‐2‐1, which produce C17H36 and C15H32, respectively. PCC 6803 transconjugants carrying these genes showed a 1.8‐ to 2.3‐fold increase in C17H36 production.
Misato Nagao, Takato Ozaki, Hirofumi Fukuda, Yu Kanesaki, Munehiko Asayama   +4 more
wiley   +1 more source

Cost benefit analysis for failure of sewer pipelines

MATEC Web of Conferences, 2017
Sewer pipelines failure in sewage networks can have adverse potential impacts on socio-economic aspects in any community. Due to the fact that it’s difficult to capture the relationship between the physical and economical aspects as a result of critical ...
Elmasry Mohamed, Hawari Alaa, Zayed Tarek   +2 more
doaj   +1 more source

DNA-GA: A New Approach of Network Performance Analysis [PDF]

, 2015
In this paper, we propose a new approach of network performance analysis, which is based on our previous works on the deterministic network analysis using the Gaussian approximation (DNA-GA). First, we extend our previous works to a signal-to-interference ratio (SIR) analysis, which makes our DNA-GA analysis a formal microscopic analysis tool.
arxiv   +1 more source