Results 71 to 80 of about 4,293,758 (238)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Impact on costs and outcomes of multi-gene panel testing for advanced solid malignancies: a cost-consequence analysis using linked administrative dataResearch in context

EClinicalMedicine
Summary: Background: To date, economic analyses of tissue-based next generation sequencing genomic profiling (NGS) for advanced solid tumors have typically required models with assumptions, with little real-world evidence on overall survival (OS ...
Alberto Hernando-Calvo, Paul Nguyen, Philippe L. Bedard, Kelvin K.W. Chan, Ramy R. Saleh, Deirdre Weymann, Celeste Yu, Eitan Amir, Dean A. Regier, Bishal Gyawali, Danielle Kain, Brooke Wilson, Craig C. Earle, Nicole Mittmann, Albiruni R. Abdul Razak, Wanrudee Isaranuwatchai, Peter Sabatini, Anna Spreafico, Tracy L. Stockley, Trevor J. Pugh, Christine Williams, Lillian L. Siu, Timothy P. Hanna   +22 more
doaj   +1 more source

Cost consequence-based reliability analysis of bursting and buckling failure modes in subsea pipelines

Journal of Ocean Engineering and Science, 2019
Risk assessment is a fundamental activity to evaluate the integrity of pipeline systems during their life cycle, which allows pipeline operators to focus attention on integrity management activities in order to prevent and mitigate failure and maintain ...
Bahram Mehrafrooz, Pedram Edalat, Mojtaba Dyanati   +2 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A cost-consequence analysis of parecoxib and opioids vs opioids alone for postoperative pain: Chinese perspective

, 2019
Magdolna Barra,1 Edit Remák,1 Dong Dong Liu,2 Li Xie,2 Lucy Abraham,3 Alesia B Sadosky4 1Evidera, Budapest, Hungary; 2Health Economics & Outcomes Research, Pfizer Investment Co., Ltd., Beijing, China; 3Health Economics & Outcomes Research,
Barra M, Liu DD, Sadosky AB, Abraham L, Remák E, Xie L   +5 more
core  

Cost-consequence analysis of influenza vaccination among the staff of a large teaching hospital in Rome, Italy: A pilot study [PDF]

, 2019
Flu vaccination, as well as being effective to prevent seasonal influenza, decreases staff illness and absenteeism and reduces costs resulting from loss of productivity. Despite the effectiveness of flu vaccination, the seasonal coverage among healthcare
Americo Cicchetti, Walter Ricciardi (15986), Andrea Barbara, Filippo Berloco, Andrea Barbara (7866200), Daniele Piacentini (7866206), Andrea Cambieri, Andrea Gentili (3425243), Patrizia Laurenti, Laurenti, Patrizia, Berloco, Filippo, Andrea Tamburrano (7866197), Piacentini, Daniele, Daniele Piacentini, Daniele Ignazio La Milia (7866203), Patrizia Laurenti (7866218), Vittoria Colamesta, Ricciardi, Walter, Andrea Gentili, Cicchetti, Americo, Gentili, Andrea, Sergio Riccardo Mastrodonato (7866212), Barbara, Andrea, Americo Cicchetti (4041329), Filippo Berloco (5508689), Roberta Galluzzi (7866209), Walter Ricciardi, Daniele Ignazio La Milia, Andrea Tamburrano, Andrea Cambieri (7866215), Vittoria Colamesta (4966333), Roberta Galluzzi, Cambieri, Andrea, Sergio Riccardo Mastrodonato   +33 more
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

MELCOR Accident Consequence Code System (MACCS) [PDF]

, 1990
Data listing for three sample problems are provided to illustrate the use of MACCS (MELCOR [We84] Accident Consequence Code System developed by Sandia National Laboratories) referred to in the accompanying report as Problems A, B, and ...
Sandia National Laboratories
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source