Results 101 to 110 of about 1,932,370 (313)

Research program on the organization and management of research and development. Questioning the cost/effectiveness of the R and D procurement process [PDF]

Cost-effectiveness evaluation of Research and Development ...
Roberts, E. B.
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Mixed-method approaches to strengthen economic evaluations in implementation research

Implementation Science, 2019
Background Guidance from economic evaluations on which implementation strategies represent the best return on investment will be critical to advancing the Triple Aim of health care: improving patient care and population health while minimizing per-capita
Alex R. Dopp, Peter Mundey, Lana O. Beasley, Jane F. Silovsky, Daniel Eisenberg   +4 more
doaj   +1 more source

Towards a cost-effectiveness analysis of the measurement of biodiversity indicators [PDF]

A comprehensive quantification of biodiversity in farming systems would require a very significant amount of work (and funds) even for a small area. Therefore, biodiversity indicators are needed to solve the problem of the measurement feasibility.
Cuming, David, Targetti, Stefano, Viaggi, Davide   +2 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Active Tuberculosis Screening via a Mobile Health App in Myanmar: Incremental Cost-Effectiveness Evaluation. [PDF]

JMIR Form Res, 2023
Htet KKK, Phyu AN, Zayar NN, Chongsuvivatwong V.   +3 more
europepmc   +1 more source

Impact Evaluations and Development: Nonie Guidance on Impact Evaluation [PDF]

, 2009
In international development, impact evaluation is principally concerned with final results of interventions (programs, projects, policy measures, reforms) on the welfare of communities, households, and individuals, including taxpayers and voters. Impact
Frans Leeuw, Jos Vaessen
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Impact of methodology on the results of economic evaluations of varicella vaccination programs: is it important for decision-making?

Cadernos de Saúde Pública
This study aims to review the literature on economic evaluation of childhood varicella vaccination programs and to discuss how heterogeneity in methodological aspects and estimation of parameters can affect the studies' results.
Patrícia Coelho de Soárez, Hillegonda Maria Dutilh Novaes, Ana Marli Christovan Sartori   +2 more
doaj  

Economic evaluations of scaling up strategies of evidence-based health interventions: a systematic review

BMC Health Services Research
Background Scaling seeks to extend the benefits of evidence-based interventions (EBIs) to larger populations, and often with the hope of achieving economies of scale. However, little is known about scaling costs. Our goal was to find scaling studies that
Adissa Bankolé, Blanchard Conombo, France Légaré, Maude Laberge   +3 more
doaj   +1 more source