Results 121 to 130 of about 1,932,370 (313)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Cost-effectiveness evaluation of risk-based breast cancer screening in Urban Hebei Province. [PDF]

Sci Rep, 2023
Shi J, Guan Y, Liang D, Li D, He Y, Liu Y.   +5 more
europepmc   +1 more source

Including patient choice in cost-effectiveness decision rules [PDF]

There has been increasing discussion in the economic literature about the appropriateness of using general population values within technology appraisal.
Dixon, S.
core  

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Cost-effectiveness evaluation of rapid initiation of antiretroviral therapy based on decision-tree Markov model. [PDF]

Chin Med J (Engl), 2023
Guan Y, Tang Q, Zhu H, Liu D, Qi T, Zhang R, Chen J, Liu L, Shen Y, Lu H.   +9 more
europepmc   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Cost-effectiveness evaluation of routine histoplasmosis screening among people living with advanced HIV disease in Latin America and the Caribbean. [PDF]

PLOS Glob Public Health, 2023
Rajasingham R, Medina N, Mousquer GT, Caceres DH, Jordan A, Nacher M, Falci DR, Sebro A, Pasqualotto AC, Sued O, Chiller T, Perez F.   +11 more
europepmc   +1 more source

NICEly does it: economic analysis within evidence-based clinical practice guidelines [PDF]

There is increasing professional and policy interest in the role of clinical guidelines for promoting effective and efficient health care. The NHS Health Technology Assessment Programme identified an urgent need, when such guidelines are produced, to ...
James Mason, Martin Eccles, Mike Drummond, Nick Freemantle   +3 more
core  

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Fine-grained mathematical modeling for cost-effectiveness evaluation of public health policies for cervical cancer, with application to a Colombian case study. [PDF]

BMC Public Health, 2023
Angulo D, Cortes MF, Mura I, Akhavan-Tabatabaei R.   +3 more
europepmc   +1 more source