Results 51 to 60 of about 1,932,370 (313)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Improving Neighborhood Location Outcomes in the Housing Choice Voucher Program: A Scan of Mobility Assistance Programs [PDF]

open access: yes, 2010
Based on interviews with housing mobility program staff, outlines issues and suggestions for assignment and sites; destination neighborhoods; measures, tracking, and outcomes; evaluation and cost effectiveness; and challenges with such ...

core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Cost-effectiveness evaluation of escitalopram in major depressive disorder in Italy

open access: yesClinicoEconomics and Outcomes Research, 2013
Claudio Mencacci,1 Guido Di Sciascio,2 Pablo Katz,3 Claudio Ripellino31Ospedale Fatebenefratelli, Milan, Italy; 2Azienda Ospedaliera Universitaria Consorziale Policlinico di Bari, Bari, Italy; 3CSD Medical Research Srl, Milan, ItalyBackground: Depression
Mencacci C   +3 more
doaj  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

The global impact and cost-effectiveness of a melioidosis vaccine

open access: yesBMC Medicine, 2019
Background Every year, 90,000 people may die from melioidosis. Vaccine candidates have not proceeded past animal studies, partly due to uncertainty around the potential market size. This study aims to estimate the potential impact, cost-effectiveness and
Nantasit Luangasanatip   +8 more
doaj   +1 more source

Health Economic Aspects of Childhood Excess Weight: A Structured Review

open access: yesChildren, 2022
An economic perspective is crucial to understand the broad consequences of childhood excess weight (CEW). These can manifest in the form of elevated health care and societal costs, impaired health status, or inefficiencies in the allocation of resources ...
Olu Onyimadu   +4 more
doaj   +1 more source

Evaluation of the generations together programme: learning so far. Research report DFE-RR082 [PDF]

open access: yes, 2011
"This report presents the findings from the evaluation of the Generations Together Demonstrator programme. This study was undertaken by York Consulting LLP on behalf of the then Department for Children, Schools and Families (DCSF); this is now the ...
Crowther, Kathryn, Merrill, Kerry
core  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

An investigation into the issue of overpackaging - examining the case of paper packaging

open access: yesInternational Journal of Sustainable Engineering, 2021
Packaging and more specifically environmentally friendly packaging has received considerable attention over the years. This paper seeks to provide an investigation into the issue of overpackaging regarding the outer paper packaging box and the various ...
E. D. Georgakoudis, N. S. Tipi
doaj   +1 more source

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