Results 71 to 80 of about 1,932,370 (313)

Effectiveness and cost-effectiveness of telehealth in rural and remote emergency departments: a systematic review protocol

Systematic Reviews, 2020
Background Emergency telehealth has been used to improve accessibility of rural and remote patients to specialist care. Evidence to date has demonstrated effectiveness and cost-effectiveness of telehealth in rural and remote emergency departments within ...
Christina Tsou, Suzanne Robinson, James Boyd, Andrew Jamieson, Robert Blakeman, Kylie Bosich, Justin Yeung, Stephanie Waters, Delia Hendrie   +8 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Surveillance strategies for Classical Swine Fever in wild boar – a comprehensive evaluation study to ensure powerful surveillance [PDF]

, 2017
Surveillance of Classical Swine Fever (CSF) should not only focus on livestock, but must also include wild boar. To prevent disease transmission into commercial pig herds, it is therefore vital to have knowledge about the disease status in wild boar.
A Catley, A Laddomada, AR Cameron, B Oidtmann, B Rechel, C Calba, C Calba, C Ebert, DU Pfeiffer, E Viennet, G Zanardi, J Hone, JA Drewe, JB Meynard, K Pearson, K Schulz, KDC Stärk, LHygienischeProbleme Briedermann, LJ Hoinville, M Artois, P Presi, R Chambers, RJ Mitchell, RM Cannon, S Blome, S Edwards, S Rossi, S von Rueden, V Kaden   +28 more
core   +4 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Economic analysis of the health impacts of housing improvement studies: a systematic review [PDF]

, 2013
Background: Economic evaluation of public policies has been advocated but rarely performed. Studies from a systematic review of the health impacts of housing improvement included data on costs and some economic analysis.
Aiga, Aiga, Allen, Allen, Allen, Ambrose, Ambrose, Ambrose, Barton, Blackman, Blackman, Bullen, Cairns, Caldwell, Catriona Macdonald, Cattaneo, Chapin, Chapman, Chapman, Clinton, Critchley, Critchley, Drummond, Edwards, Eick, Elisabeth Fenwick, Gilbertson, Green, Green, Grimes, Halpern, Harrington, Heyman, Heyman, Heyman, Hilary Thomson, Hjelmgren, Hong, Howden-Chapman, Howden-Chapman, Howden-Chapman, Hutchinson, Huxley, Jackson, Joffe, Kelly, Laing, Lloyd, Mackenzie, McGonigle, McIntosh, National Institute for Health and Clinical Excellence, National Prescribing Centre, Oreszczyn, Platt, Rugkasa, Rugkåsa, Sedky, Shaw, Shiell, Shiell, Shortt, Somerville, Somerville, Sugden, Thomas, Thomson, Thomson, Thomson, US Taskforce on Community Preventive Services, Walker, Wanless, Wolff, Woodin   +73 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Comment on Gomez et. al. “Response to article by Wasserman et. al. (2018) ‘Modelling the sustained use of the 13-valent pneumococcal conjugate vaccine compared to switching to the 10-valent vaccine in Mexico’”

Human Vaccines & Immunotherapeutics, 2019
In a recent Letter, Gomez et. al. provided a critique of our original analysis estimating the clinical and economic impact of switching from the 13-valent (PCV13) to the 10-valent (PCV10) pneumococcal conjugate vaccine in Mexico.
Matt Wasserman, Maria Gabriela Palacios, Ana Gabriela Grajales, Michele Wilson, Cheryl McDade, Raymond Farkouh   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Design improvement of toner cartridge using design for assembly method [PDF]

, 2020
DFMA or known as Design for Manufacture and Assembly, consists of two main components which are Design for Manufacturing and Design for Assembly. To review the design for product evaluation, DFMA is an important methodolgy to be used. Reducing the number
Hehsan, Haffidzudin, Nordin, Muhammad Alif Haziq   +1 more
core  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source