Results 41 to 50 of about 713,344 (287)

CLINICAL AND ECONOMIC EVALUATION OF THROMBOPOIETIN RECEPTOR AGONISTS IN THE TREATMENT OF CHRONIC IDIOPATHIC THROMBOCYTOPENIC PURPURA IN ADULTS

Фармакоэкономика, 2016
Aim. Hospital-based economic analysis for the use of thrombopoietin receptor agonists (TRA) Eltrombopag and Romiplostim has been performed in patients with chronic idiopathic thrombocytopenic purpura (ITP) at the background failure of previous treatment ...
E. A. Pyadushkina, M. Yu. Frolov, M. V. Avksentyeva   +2 more
doaj   +1 more source

Can Aging in Place Be Cost Effective? A Systematic Review

, 2014
Purpose of the Study - To systematically review cost, cost-minimization and cost-effectiveness studies for assisted living technologies (ALTs) that specifically enable older people to ‘age in place’ and highlight what further research is needed to inform
Quinn, Terence, Wildman, John, McMeekin, Peter, Graybill, Erin   +3 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Pharmaco-economics analysis, as a strategy on facilitating choices between health and non-health programs in the establishment of the national health care system

Alexandria Journal of Medicine, 2014
Due to the significant boost in community expenditure with health topics, mainly regarding drugs, numerous countries, have already put into operation, or are in the process of arguing the adoption of actions to guarantee the excellence of health care ...
Adanela Musaraj, Arta Musaraj, Aida Dervishi   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Pharmacoeconomic analysis of tiotropium bromide and olodaterol fixed combination as maintenance therapy for patients with COPD in the Russian Federation

Фармакоэкономика, 2020
Aim. To assess the economic efficacy of a fixed combination tiotropium bromide+olodaterol (T+O) in comparison with other medications, included in the Vital and Essential Drugs List (VEDL), for the maintenance triple therapy of chronic obstructive ...
S. V. Nedogoda, M. Yu. Frolov, A. S. Salasyuk, I. N. Barykina, V. O. Smirnova   +4 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Analysis of cost minimization methods in geo-distributed data centers

, 2016
Significant growth of Big Data leads to a great opportunity for data analysis. Data centers are continuously becoming more popular. At the same time data centers’ cost are increasing as the amount of data is growing.
Khalaf, Ayesheh Ahrari, Aisha Hassan Abdalla, Hassan Abdalla Hashim, Aisha, Ayesheh Ahrari Khalaf   +3 more
core   +1 more source

Cost minimization analysis of laparoscopic surgery for colorectal cancer within the enhanced recovery after surgery (ERAS) protocol: a single-centre, case-matched study [PDF]

, 2016
Introduction: The goal of modern medical treatment is to provide high quality medical care in a cost-effective environment. Aim : To assess the cost-effectiveness of laparoscopic colorectal surgery combined with the enhanced recovery after surgery ...
Michał Kisielewski, Stanisław Kłęk, Magdalena Pisarska, Nowakowski, Michał, Michał Nowakowski, Maciej Stanek, Matłok, Maciej, Pędziwiatr, Michał, Pisarska, Magdalena, Budzyński, Andrzej, Major, Piotr, Stanek, Maciej, Mateusz Wierdak, Michał Pędziwiatr, Piotr Major, Kłęk, Stanisław, Andrzej Budzyński, Kisielewski, Michał, Maciej Matłok, Wierdak, Mateusz   +19 more
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source