Results 91 to 100 of about 309,449 (261)

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Atomic‐Level CuOx‐CoOx‐Pd Interfacial Engineering Enables Hierarchical Synergy for High‐Efficiency ORR Pathways and Boosted Power Output in Alkaline Fuel Cells

Advanced Science, EarlyView.
Atomically dispersed CuOx (CPCu‐1) forms isolated Cu–Ov sites that enable defect‐mediated O2 activation and fast electron/proton transfer via interfacial synergy. In contrast, thick CuOx clusters (CPCu‐10) promote a surface‐adsorption‐controlled pathway with intermediate accumulation, highlighting a mechanism switch from interfacial activation to ...
Yang‐Yang Hsu, Ching‐Hua Fan, Kuan‐Wen Wang, Kuang‐Kuo Wang, Nozomu Hiraoka, Hirofumi Ishii, Ting‐Shan Chan, Po‐Chun Chen, Tsan‐Yao Chen   +8 more
wiley   +1 more source

Annual societal cost of Alzheimer’s disease in Malaysia: a micro-costing approach

BMC Geriatrics
Background Alzheimer’s disease (AD) is expected to have a significant impact on resource use and economic consequences along with population aging. This study aims to investigate the annual economic burden of Alzheimer’s disease along with underlying ...
Siew Chin Ong, Lyn Xuan Tay, Hui Ming Ong, Ing Khieng Tiong, Alan Swee Hock Ch‘ng, Thaigarajan Parumasivam   +5 more
doaj   +1 more source

Conformal Reconfigurable Intelligent Surfaces: A Cylindrical Geometry Perspective

Advanced Electronic Materials, EarlyView.
Cylindrical reconfigurable intelligent surfaces are explored for low‐complexity beam steering using one‐bit meta‐atoms. A multi‐level modeling approach, including optimization‐based synthesis, demonstrates that even minimal hardware can support directive scattering.
Filippo Pepe, Ivan Iudice, Giuseppe Castaldi, Marco Di Renzo, Vincenzo Galdi   +4 more
wiley   +1 more source

The cost-of-illness of multiple sclerosis in Jordan

Expert Review of Pharmacoeconomics & Outcomes Research
Multiple Sclerosis (MS) imposes a significant financial burden on health-care systems. This study aims to determine the cost-of-illness (COI) for MS in Jordan, a country where data on the economic impact of MS are scarce. Data were collected for one year, annual COI was estimated using a cross-sectional snowball sampling design.
Ibrahim Alabbadi, Sara Al-Ajlouny, Yazan Alsoud, Ayah BaniHani, Bayan A. Arar, Eman M. Massad, Suhaib Muflih, Mays Shawawrah   +7 more
openaire   +2 more sources

The incremental healthcare cost associated with cancer in Belgium: A registry‐based data analysis

Cancer Medicine
Background Similar to many countries, Belgium experienced a rapid increase in cancer diagnoses in the last years. Considering that a large part of cancer types could be prevented, our study aimed to estimate the annual healthcare burden of cancer per ...
Vanessa Gorasso, Stefanie Vandevijvere, Johan Van der Heyden, Ingrid Pelgrims, Henk Hilderink, Wilma Nusselder, Claire Demoury, Masja Schmidt, Stijn Vansteelandt, Delphine De Smedt, Brecht Devleesschauwer   +10 more
doaj   +1 more source

Updatable Closed‐Form Evaluation of Arbitrarily Complex Multiport Network Connections

Advanced Electronic Materials, EarlyView.
The inverse design of electrically large wave devices often uses reduced‐order multiport models with discrete optimization, requiring many evaluations of complex interconnections between subsystems that differ only in a few blocks. This paper introduces a closed‐form framework enabling efficient Woodbury low‐rank updates of related, previous ...
Hugo Prod'homme, Philipp del Hougne
wiley   +1 more source

Global economic burden of schizophrenia: letter in response

Neuropsychiatric Disease and Treatment, 2016
Amanda L Neil,1 Vaughan J Carr2,31Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, 2Research Unit for Schizophrenia Epidemiology, School of Psychiatry, University of New South Wales, Sydney, New South Wales, 3Department ...
Neil AL, Carr VJ
doaj  

People Counting and Positioning Using Low‐Resolution Infrared Images for FeFET‐Based In‐Memory Computing

Advanced Electronic Materials, EarlyView.
In this work, low‐resolution infrared imaging is combined with a 28 nm FeFET IMC architecture to enable compact, energy‐efficient edge inference. MLC FeFET devices are experimentally characterized, and controlled multi‐level current accumulation is validated at crossbar array level.
Alptekin Vardar, Li Zhang, Alexander Rehmer, Marc Lupp, Subhashree Baskaran, Osama Abdelaal, Franz Müller, Nandakishor Yadav, Bing Li, Thomas Kämpfe   +9 more
wiley   +1 more source

Comparative Insights and Overlooked Factors of Interphase Chemistry in Alkali Metal‐Ion Batteries

Advanced Energy Materials, EarlyView.
This review presents a comparative analysis of Li‐, Na‐, and K‐ion batteries, focusing on the critical role of electrode–electrolyte interphases. It especially highlights overlooked aspects such as SEI/CEI misconceptions, binder effects, and self‐discharge relevance, emphasizing the limitations of current understanding and offering strategies for ...
Changhee Lee, Zachary T. Gossage, Shinichi Kumakura, Shinichi Komaba   +3 more
wiley   +1 more source