Results 111 to 120 of about 2,377,300 (402)

Mechanical thrombectomy in patients with acute ischemic stroke: a cost-utility analysis.

CMAJ Open, 2016
BACKGROUND The beneficial effects of endovascular treatment with new-generation mechanical thrombectomy devices compared with intravenous thrombolysis alone to treat acute large-artery ischemic stroke have been shown in randomized controlled trials (RCTs)
Xuanqian Xie, Anna Lambrinos, B. Chan, I. Dhalla, T. Krings, L. Casaubon, C. Lum, N. Sikich, A. Bharatha, V. Pereira, G. Stotts, G. Saposnik, C. O'callaghan, L. Kelloway, M. Hill   +14 more
semanticscholar   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Cost-utility of transcatheter aortic valve implantation for inoperable patients with severe aortic stenosis treated by medical management: a UK cost-utility analysis based on patient-level data from the ADVANCE study. [PDF]

, 2014
OBJECTIVE: To use patient-level data from the ADVANCE study to evaluate the cost-effectiveness of transcatheter aortic valve implantation (TAVI) compared to medical management (MM) in patients with severe aortic stenosis from the perspective of the UK ...
Bleiziffer, S, Bosmans, J, Brecker, S, Busca, R, Eaton, J, Gerckens, UJ, Linke, A, Mealing, S, Moat, N, Padhiar, A, Piazza, N, Sculpher, M, Tamburino, C, Wenaweser, P   +13 more
core   +1 more source

Cost–Utility Analysis of Cochlear Implantation in Australian Adults

Otology and Neurotology, 2016
Objectives: Sequential and simultaneous bilateral cochlear implants are emerging as appropriate treatment options for Australian adults with sensory deficits in both cochleae.
C. Foteff, Steven P. Kennedy, A. Milton, Melike Deger, Florian Payk, Georgina Sanderson   +5 more
semanticscholar   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Study of Lyndon B. Johnson Space Center utility systems [PDF]

The results of an engineering study of potential energy saving utility system modifications for the NASA Lyndon B. Johnson Space Center are presented. The objective of the study was to define and analyze utility options that would provide facility energy
Huber, W. C., Redding, T. E.
core   +1 more source

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, Volume 15, Issue 7, Page 1079-1089, July 2025.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

Cost-effectiveness of combination therapy umeclidinium/vilanterol versus tiotropium in symptomatic COPD Spanish patients

International Journal of COPD, 2016
Marc Miravitlles,1 Juan B Gáldiz,2 Alicia Huerta,3 Alba Villacampa,4 David Carcedo,4 Francisco Garcia-Rio5 1Pneumology Department, Hospital Universitari Vall d’Hebron, CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, 2Pneumology ...
Miravitlles M, Gáldiz JB, Huerta A, Villacampa A, Carcedo D, Garcia-Rio F   +5 more
doaj  

Shunt surgery in idiopathic normal pressure hydrocephalus is cost-effective—a cost utility analysis

Acta Neurochirurgica, 2017
BackgroundThe objective was to evaluate the cost-effectiveness of shunt surgery in patients with idiopathic normal pressure hydrocephalus (iNPH).MethodsHealth-related quality of life was evaluated before and 6 months after surgery using the EQ-5D-3 L ...
M. Tullberg, Josefine Persson, Jakob Petersen, P. Hellström, C. Wikkelsø, Å. Lundgren-Nilsson   +5 more
semanticscholar   +1 more source

Construction of hyperthermostable d‐allulose 3‐epimerase from Arthrobacter globiformis M30 using the sequence information from Arthrobacter psychrolactophilus

FEBS Open Bio, EarlyView.
d‐Allulose can be produced from d‐fructose by d‐allulose 3‐epimerase. Based on sequence homology information, we successfully engineered thermostable mutants with the protein engineering method. By integrating positive mutations, we constructed an enzyme that exhibits hyperthermostability without a loss in the activity.
Kensaku Shimada, Kouhei Ohtani, Pushpa Kiran Gullapalli, Kazuhiko Ishikawa   +3 more
wiley   +1 more source